19625-68-4

Upstream product

• 603-71-4 nitromesitylene 
• 104217-83-6 1,3,5-tris-(4-methoxy-phenyl)-2-nitro-benzene 

Downstream Products

• 19715-79-8 nitro-benzene-1,3,5-tricarboxylic acid trimethyl ester 
• 489-96-3 2-amino-1,3,5-benzenetricarboxylic acid 

Relevant academic research and scientific papers

Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the MECAM core, which are imported by bacterial iron uptake systems. Structures, spin states, and iron binding properties were predicted in silico using density functional theory. The capability of MECAM to function as an effective artificial siderophore in Escherichia coli was proven in microbiological growth recovery and bioanalytical assays. Following a linker optimization focused on transport efficiency, five β-lactam and one daptomycin conjugates were prepared. The most potent conjugate 27 showed growth inhibition of Gram-positive and Gram-negative multidrug-resistant pathogens at nanomolar concentrations. The uptake pathway of MECAMs was deciphered by knockout mutants and highlighted the relevance of FepA, CirA, and Fiu. Resistance against 27 was mediated by a mutation in the gene encoding ExbB, which is involved in siderophore transport.

Positive-working immobile intramolecular nucleophilic displacement compounds and photographic elements containing same

Novel photographic dye release compounds have the structure: STR1 wherein R1 is an aromatic group containing 5-7 members in the ring to which Nu and E are attached; R2 and R3 are bivalent organic groups containing from 1-3 atoms in the bivalent linkage which are alkylene, oxyalkylene or thiaalkylene; Nu is a nucleophilic group which is a hydrazine, an hydroxyamino, an hydroxy, a sulfonamido, a primary amino or alkali-labile precursors for said nucleophilic groups; E is an electrophilic group which is a carbonyl or a sulfonyl; Q is a bivalent group providing a mono atom linkage between E and X2 and is amino providing a mono atom nitrogen linkage, an oxygen atom, a sulfur atom or a selenium atom, provided that Nu and E are positioned on a ring of said aromatic group to provide for intramolecular formation of a 5- to 7-membered ring between Nu and E displacing Q--X2 from E; one of X1 or Q--X2 is a ballasting group containing at least 8 carbon atoms, which ballasting group is of a size sufficient to render said compound immobile in an alkaline solution-permeable layer of a photographic element; one of X1 or Q--X2 is an azo dye, an azomethine dye; an anthraquinone dye, an alizarin dye, a merocyanine dye, a quinoline dye or a cyanine dye; and n and m are integers of 1 or 2.