1963-42-4

Usage

Chemical structure

A pyrrole derivative with a benzyl group substituted with a methoxy group

Usage

Synthesis of various pharmaceuticals and organic compounds

Unique properties

Offers unique chemical properties for synthesis

Pharmacological activities

Potential as an anticancer agent and as an inhibitor of specific enzymes

Research areas

Medicinal chemistry, materials science, and pharmaceutical research

Additional applications

Development of organic electronic materials

Upstream product

• 1003-29-8 2-pyrrole aldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 18159-24-5 1-benzyl-1H-pyrrole-2-carbaldehyde 
• 1963-43-5 (4-methoxyphenyl)(1H-pyrrol-2-yl)methanone 

Downstream Products

• 22862-67-5 2-[(4-methoxyphenyl)methyl]-2,5-dihydro-(1H)-pyrrole 
• 24064-16-2 benzyl 2-[(4-methoxyphenyl)methyl]-2,5-dihydropyrrole-1-carboxylate 
• 19713-95-2 rac.-Desacetylanisomycin 
• 21497-40-5 (+/-)-anisomycin 
• 82916-85-6 2β-(p-methoxybenzyl)-3,4β-oxidopyrrolidine 
• 82916-87-8 4β-acetoxy-3α-hydroxy-2β-(p-methoxybenzyl)pyrrolidine 
• 34869-05-1 N-((benzyloxy)carbonyl)-2β-(p-methoxybenzyl)-3,4β-oxidopyrrolidine 
• 82892-41-9 N-((benzyloxy)carbonyl)-4β-hydroxy-3α-iodo-2β-(p-methoxybenzyl)pyrrolidine 
• 82916-86-7 N-((benzyloxy)carbonyl)-3β,4α-dihydroxy-2β-(p-methoxybenzyl)pyrrolidine 
• 111602-18-7 (2S,3R,4R)-3-Acetoxy-2-(4-methoxy-benzyl)-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

In Situ vinylpyrrole synthesis. Diels-alder reactions with maleimides to give tetrahydroindoles

(Chemical Equation Presented) A series of 108 tetrahydroindoles has been prepared by a one-pot synthesis from 2-alkylpyrroles, cyclic ketones, maleimides, and an acid catalyst. A 5-vinylpyrrole is formed by an acid-catalyzed condensation of a 2-alkyl-substituted pyrrole with a ketone, which is subsequently trapped in situ by a maleimide in a predominantly endo-addition Diels-Alder reaction. Isomerization of the double bond into the pyrrole ring gives a tetrahydroindole with predominant cis-fusion of the cycloalkane ring.

A General Method for the Preparation of 2-Benzylpyrroles by Modified Borohydride Reduction of Azafulvenium Salts

2-Benzylpyrroles (5a-h) can be prepared in high yield from pyrroles by reduction, with modified borohydride reagents, of the corresponding 1-azafulvenium salts (3a-h) generated in situ in the presence of excess of phosphoryl trichloride.The procedure is compatible with ester groups.

Tandem Alkylation-Reduction of 2-Acylpyrroles. Convenient One-Pot Syntheses of 2-Benzylpyrroles

Tandem alkylation-reduction of 2-acylpyrroles is described for the convenient one-pot syntheses of 2-benzylpyrroles.By this convenient procedure 2-(p-methoxybenzyl)pyrrole (2), 2-benzylpyrrole (3), 2-(p-methylbenzyl)pyrrole (4), 2-(o-methoxybenzyl)pyrrole