196313-99-2Relevant academic research and scientific papers
Synthesis of the tetrahydrooxazolo [2,3-b] [3] benzazepin-3 (2H)-one system and x-ray crystal structure of an 11a-ethoxy derivative
Bremner, John B.,Rezaie, Robert,Skelton, Brian W.,White, Allan H.
, p. 759 - 762 (2007/10/03)
Photolysis of the N-chloroacetyl imide derivative 3-chloroacetyl-7,8-dimethoxy-4,5-dihydro-1H-3-benzazepin-2(3H)-one (2) in aqueous acetonitrile gave 11a-hydroxy-8,9-dimethoxy-5,6,11,11a-tetrahydrooxazolo[2,3-b][3] benzazepin-3(2H)-one (4) in 81% yield. This representative of a new heterocyclic system could be converted into the 11a-ethoxy derivative (5) by recrystallization from ethanol. The structure of (5) was confirmed by a room-temperature single-crystal X-ray study. Crystals are monoclinic, Cc, a 17.623(9), b 7.550(4), c 12.872(3) A, β 112.55(4)°, Z = 4; conventional R on |F| was 0.034 for 1072 'observed' (I > 3σ(I)) reflections.
