196394-91-9Relevant academic research and scientific papers
PROCESS FOR SYNTHESIS OF TRITIATED AND DEUTERATED THIORPHAN AND ACETORPHAN
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Page/Page column 19, (2009/07/18)
Methods for preparing tritium or deuterium labeled thiorphan comprising reacting a compound of formula (j), wherein m is from 1 to 5 and X is halo, with Z2 wherein Z is tritium or deuterium, in the presence of a catalyst, to form a compound of formula (k)
Synthesis of tritium labelled thiorphan, an enkephalinase inhibitor
Wu, Shao-Yong,Masjedizadeh, Mohammad R.
experimental part, p. 23 - 28 (2009/05/09)
Tritium labelling of the enkephalinase inhibitor, thiorphan, is complicated by the presence of mercapto functional group. Reactions often used in aromatic tritiation, such as halogination and catalytic halogen/tritium displacement, are adversely affected
Thiol inhibitors of endothelin-converting enzyme
Deprez, Pierre,Guillaume, Jacques,Dumas, Jacques,Vevert, Jean-Paul
, p. 2317 - 2322 (2007/10/03)
Synthesis and structure activity relationships of a series of thiol inhibitors of the endothelin-converting enzyme (ECE) are presented. Optimisation of the stereochemistry as well as of the P'1 and P'2 residues led to inhibitors with similar potency to that of phosphoramidon.
