196406-94-7

Upstream product

• 89429-83-4 dl-trans-2-benzyloxymethyltetrahydropyran-3-ol 
• 3587-60-8 Benzyloxymethyl chloride 
• 51450-45-4 (2R,3S)-2-hydroxymethyltetrahydropyran-3-ol 
• 100-39-0 benzyl bromide 
• 110-87-2 3,4-dihydro-2H-pyran 
• 89429-82-3 6-benzyloxymethyl-3,4-dihydro-2H-pyran 

Downstream Products

• 196406-82-3 (R)-2-Benzyloxymethyl-dihydro-pyran-3-one 
• 1437318-74-5 C₃₀H₄₂O₇ 
• 196309-40-7 C₂₀H₂₈O₅ 

Relevant academic research and scientific papers

Correlation between conformational equilibria of free host and guest binding affinity in non-preorganized receptors

Positive cooperativity between host conformational equilibria and guest binding has been widely reported in protein receptors. However, reported examples of this kind of cooperativity in synthetic hosts are scarce and largely serendipitous, among other th

Convergent Synthesis of a Trans-fused 6-7-6 Tricyclic Ether System Based on a Ring-closing Metathesis Reaction

Synthesis of a trans-fused 6-7-6 tricyclic ether system was achieved via stereoselective acetal formation, reductive cleavage of the acetal, and a ring-closing metathesis reaction.

HIV protease inhibitors useful for the treatment of aids

Compounds of the form,ψ ψ A-G-Jψ ψ wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.ψ