196409-10-6Relevant academic research and scientific papers
Baker's yeast reduction of (E)-1-phenyl-1,2-propanedione 2-(O-methyloxime). A key step for a (-)-norephedrine synthesis
Kreutz, Olyr C.,Moran, Paulo J. S.,Rodrigues, J. Augusto R.
, p. 2649 - 2653 (1997)
The enantioselective Baker's yeast reduction of (E)-1-phenyl-1,2-propanedione 2-(O-methyloxime) 1 afforded (-)-(R)-1-hydroxy-1-phenyl-2-propanone 2-(O-methyloxime) 2 with 97% of enantiomeric excess (ee) which was diastereoselectively reduced by LiAlH4 to obtain the (-)-(R,S)-norephedrine with ee=82% and (-)-(R,R)-norpseudoephedrine with ee=93% in a ratio 4:1 respectively.
Enantioselective bioreduction of (E)-1-phenyl-1,2-alkanedione 2-(O-methyloxime)
Kreutz, Olyr C.,Segura, Renata C. M.,Rodrigues, J. Augusto R.,Moran, Paulo J. S.
, p. 2107 - 2115 (2007/10/03)
The baker's yeast reduction of (E)-1-phenyl-1,2-alkanedione 2-(O-methyloxime), PhC(O)C(NOMe)R (R=Me, Et, n-Pr, n-Bu), gave the corresponding optically active alcohols PhCH2OHC(NOMe)R in 88-99% enantiomeric excess and 48-75% chemical yield. The
