196411-25-3Relevant academic research and scientific papers
Stereoselective synthesis of cis-5-alkyl-(S)-prolines from (S)-pyroglutamic acid via 5-alkyl-5-hydroxy-(S)-prolines
Li, Hao,Sakamoto, Takeshi,Kikugawa, Yasuo
, p. 6677 - 6680 (1997)
Introduction of alkyl groups with trialkylaluminums in the 5-position of the pyroglutamic ring system without ring opening and subsequent hydrogenation over Pt/C lead to exclusively cis-5-alkyl-(S)-prolines without epimerization of the chiral centre.
