Stereoselective synthesis of cis-5-alkyl-(S)-prolines from (S)-pyroglutamic acid via 5-alkyl-5-hydroxy-(S)-prolines

DOI: 10.1016/S0040-4039(97)01563-3

Source and publish data:

Tetrahedron Letters p. 6677 - 6680 (1997)

Update date:2022-08-05

Topics:

Authors:

Li, Hao Li, Hao

Sakamoto, Takeshi

Kikugawa, Yasuo

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Article abstract of DOI:10.1016/S0040-4039(97)01563-3

Introduction of alkyl groups with trialkylaluminums in the 5-position of the pyroglutamic ring system without ring opening and subsequent hydrogenation over Pt/C lead to exclusively cis-5-alkyl-(S)-prolines without epimerization of the chiral centre.

Full text of DOI:10.1016/S0040-4039(97)01563-3

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Product name:(S)-5-Hydroxy-5-methyl-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester

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