196505-07-4

Upstream product

• 183740-05-8 5-amino-1-benzyl-4-cyano-3-(3-methoxy-phenyl)-pyrazole 
• 183740-02-5 2-Cyano-3-(3-methoxy-phenyl)-3-methylmercapto-acrylonitrile 
• 20570-96-1 benzylhydrazine dihydrochloride 
• 37407-45-7 methyl (m-methoxyphenyl)carbodithioate 
• 196505-05-2 1-benzyl-4-hydroxy-3-(3-methoxy-phenyl)-pyrazolo[3,4-d]pyrimidine 

Downstream Products

• 183740-13-8 1-benzyl-4-(3-chloro-phenylamino)-3-(3-methoxy-phenyl)-pyrazolo[3,4-d]pyrimidine 

Relevant academic research and scientific papers

Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP- competitive inhibitors interacting w