196520-02-2Relevant academic research and scientific papers
Syntheses and evaluation of naphthalenyl- and chromenyl-pyrrol-benzoic acids as potent and selective retinoic acid receptor α agonists
Hibi, Shigeki,Tagami, Katsuya,Kikuchi, Kouichi,Yoshimura, Hiroyuki,Tai, Kenji,Hida, Takayuki,Tokuhara, Naoki,Yamauchi, Toshihiko,Nagai, Mitsuo
, p. 623 - 625 (2007/10/03)
Synthesis and structure-activity relationships (SAR) of RARα-selective agonists are discussed. 4-[5-(5,8-Dimethyl-2H-3-chromenyl)-1H-2-pyrrolyl]benzo ic acid (12a), which possesses a flat structural moiety and an oxygen atom at the hydrophobic part, showed highly selective transactivation activity at the RARα receptor. (C) 2000 Elsevier Science Ltd. All rights reserved.
