19655-69-7

Upstream product

• 104-94-9 4-methoxy-aniline 
• 100-47-0 benzonitrile 
• 696-62-8 para-iodoanisole 
• 1670-14-0 benzamidine monohydrochloride 
• 618-39-3 benzamidin 
• 55-21-0 benzamide 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 35371-23-4 1-(4-methoxy-phenyl)-4-(3-methyl-benzo[b]thiophen-2-yl)-2-phenyl-1H-imidazole 
• 89646-94-6 (4R,5R)-1-(4-Methoxy-phenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazol-4-ol 
• 89646-88-8 4-[1-(4-Methoxy-phenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazol-4-yl]-morpholine 
• 89060-64-0 1,5-diphenyl-3-methoxycarbonal-1,2,4-triazole 
• 74668-99-8 3-(4-Methoxy-phenyl)-2-phenyl-5-(phenyl-hydrazono)-3,5-dihydro-imidazol-4-one 
• 104-94-9 4-methoxy-aniline 
• 1242182-91-7 6-methoxy-2-phenyl-4-[(triisopropylsilyl)methyl]quinazoline 
• 1151-70-8 6-methoxy-2-phenyl-quinazolinone-4(3H)-one 
• 1315314-52-3 6-methoxy-2,4-diphenylquinazoline 
• 94542-54-8 1-(4-methoxy-phenyl)-2-phenyl-1H-benzoimidazole 
• 1198463-94-3 (5-methoxy-2-phenyl-1H-indol-3-yl) (phenyl)methanone 
• 74638-03-2 phenylcarbamoyl-(4-methoxyphenyl)benzamidine 

Relevant academic research and scientific papers

An eco-friendly approach for the synthesis of 1,2,5-trisubstituted and 4-amino-1,2,5-tetrasubstituted imidazoles via a multi-component condensation

The synthesis of 1,2,5-trisubstituted and 4-amino-1,2,5-tetrasubstituted imidazoles was demonstrated via a two-step cyclo-condensation reaction of aryl amines, carbonitriles, and ethyl bromopyruvate or aryl amines and arylglyoxals in ethanol heated under

Transition-Metal-Free Synthesis of 1,2-diphenyl-1H-benzo[d] Imidazole Derivatives from N-phenylbenzimidamides and Cyclohexanones

A transition-metal-free strategy for the formation of 1,2-diphenyl-1H-benzo[d] imidazoles from N-phenylbenzimidamides and cyclohexanones is introduced. This is the first report on the direct synthesis of 1,2-diphenyl-1H-benzo[d] imidazoles from cyclohexanones and N-phenylbenzimidamides via iodine- promoted oxidative cyclization. Non-aromatic cyclohexanones were smoothly dehydrogenated, and acted as an aryl source using oxygen as a green oxidant. The catalytic use of iodine makes this method quite simple, more economical and convenient. Under optimized conditions, various substituted 1,2-diphenyl-1H-benzo[d] imidazoles were smoothly reacted, and the desired substituted imidazoles were generated with moderate to excellent yields. (Figure presented.).

Metal-Free Synthesis of Polysubstituted Imidazolinone Through Cyclization of Amidines with 2-Substituted Acrylates

Polysubstituted imidazolinones were synthesized in a facile metal-free cascade nucleophilic cyclization of easily available amidines and 2-substituted acrylates. This protocol is distinguished by simple, mild, and catalyst-free reaction conditions with a broad substrate scope, affording the desired products in moderate to good yields and providing an efficient strategy for synthesis of polysubstituted imidazolinone.

Base-Mediated Amination of Alcohols Using Amidines

Novel and efficient base-mediated N-alkylation and amidation of amidines with alcohols have been developed, which can be carried out in one-pot reaction conditions, which allows for the synthesis of a wide range of N-alkyl amines and free amides in good to excellent yields with high atom economy. In contrast to borrowing hydrogen/hydrogen autotransfer or oxidative-type N-alkylation reactions, in which alcohols are activated by transition-metal-catalyzed or oxidative aerobic dehydrogenation, the use of amidines provides an effective surrogate of amines. This circumvents the inherent necessity in N-alkylation of an oxidant or a catalyst to be stabilized by ligands.

Synthesis of 1,2-dihydro-1,3,5-triazine derivativesviaCu(ii)-catalyzed C(sp3)-H activation ofN,N-dimethylethanolamine with amidines

1,2-Dihydro-1,3,5-triazines and symmetrical 1,3,5-triazines were obtained in up to 81% yields from amidines andN,N-dimethylethanolamine catalyzed by CuCl2. The reaction involves three C-N bond formations during the oxidative annulation process

Synthesis of 1,2,4,5-tetrasubstituted imidazoles and 2,4,5,6-tetrasubstituted pyrimidines: three-component, the one-pot reaction of arylamidines, malononitrile, and arylglyoxals or aryl aldehydes

A highly efficient one-pot synthesis of the 1,2,4,5-tetrasubstituted imidazoles and 2,4,5,6-tetrasubstituted pyrimidines through an arylamidine, malononitrile, and carbonyl compound by using Et3N in CH3CN at reflux conditions was dev

Calcium mediated efficient synthesis ofN-arylamidines from organic nitriles and amines

Amidines are a preeminent group of organic compounds having wide applications in various industries. Here, we have developed a simple one-step reaction protocol for the facile synthesis ofN-arylamidines catalysed by calcium bis(hexamethyldisilazide) [Ca{N

Acid-catalyzed synthesis of imidazole derivatives via N-phenylbenzimidamides and sulfoxonium ylides cyclization

A straightforward method to synthesize imidazole derivatives from amidines and sulfoxonium ylides catalyzed by acids is reported in this study. Specifically, catalyzed by trifluoroacetic acid in DCE solvents can improve synthesis efficiency under metal-fr

Metal-Free C-B Bond Cleavage: An Acid Catalyzed Three-Component Reaction Construction of Imidazole-Containing Triarylmethanes

An efficient acid-catalyzed strategy to prepare imidazole-containing triarylmethanes from amidines, ynals, and boronic acids has been developed. It represents an unprecedented and novel metal-free C-B bond cleavage strategy as a workable route to form new carbon-carbon bonds.

Transition-metal-free three-component reaction: Additive controlled synthesis of sulfonylated imidazoles

Two efficient transition-metal-free highly regioselective pathways for constructing sulfonylated imidazoles via three-component reactions of amidines, ynals, and sodium sulfonates have been developed. The generations of different sulfonylated imidazoles w