196608-06-7

Upstream product

• 67-56-1 methanol 
• 85889-27-6 3-O-β-D-glucuronopyranoside of hederagenin 
• 97892-84-7 (1S,3S,4S,5R,6R)-6-Hydroxy-5-((2S,3R,4S,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy)-2,7-dioxa-bicyclo[2.2.1]heptane-3-carboxylic acid methyl ester 
• 97892-80-3 Methyl O-β-D-galactopyranosyl-(1->2)-O-α-L-arabinopyranosyl-(1->3)-1,4-anhydro-α-D-glucopyranuronate 
• 97892-79-0 Methyl 2)-O-α-L-arabinopyranosyl-(1->3)-α-D-glucopyranosid>uronate 
• 112408-70-5 5,7'-dihydroxy-8,2'-dimethoxyflavone 7-O-β-D-glucuronopyranoside 
• 112408-69-2 2(S)-5,2'-dihydroxy-7,8,6'-trimethoxyflavanone 2'-O-β-D-glucuronopyranoside 
• 26020-14-4 calenduloside E 
• 6556-12-3 D-glucuronic acid 

Relevant academic research and scientific papers

Antioxidant and semicarbazide-sensitive amine oxidase inhibitory activities of glucuronic acid hydroxamate

The antioxidant and inhibitory activities of glucuronic acid (GluA) and its synthesized 1-methoxyl-6-glucuronic acid hydroxamate (GluA-NHOH) against semicarbazide-sensitive amine oxidase (SSAO) were investigated. The scavenging activities of GluA-NHOH aga

Synthesis and evaluation of glucuronic acid derivatives as alkylating agents for the reversible masking of internucleoside groups of antisense oligonucleotides

2-Iodoethyl (methyl α-D-glucopyranosid)uronate and 2-iodoethyl (methyl β-D-glucopyranosid)thiouronate were prepared in five steps by an efficient synthetic route starting from D-glucuronic acid. Both compounds were used to alkylate dithymidine phosphorothioate and phosphorodithioate diesters, leading to the corresponding phosphotriesters 12 to 15. Hydrolytic stability of 12-15 was studied in different biological media. The enzymatic hydrolysis of 12-15 was accompanied by another reaction resulting in formation of the dithymidine phosphodiesters. Several possible mechanisms for these reactions are proposed.

Studies on the Constituents of Solanaceous Plants. XIII. A New Steroidal Glucuronide from Chinese Solanum lyratum

A new glucuronide, (22R)-3β,16β,22,26-tetrahydroxycholest-5-ene 3-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucuronopyranoside (1), was isolated from the aerial parts of Chinese Solanum lyratum THUNB.The structure of this new steroidal glucuronide was deduced by spectroscopic means and the identity of its aglycone was substantiated by comparison with an authentic sample derived from diosgenin acetate.Keywords - Solanaceae; Solanum lyratum; (22R)-3β,16β,22,26-tetrahydroxycholest-5-ene; rhamnosyl glucuronoside; diosgenin E,F-ring cleavage; aluminum chloride-acetic anhydride reaction.

Studies on the Constituents of Scutellaria Species. IX. On the Flavonoid Constituents of the Root of Scutellaria indica

Four new flavanones (I-IV) and a new flavone (V) were isolated from the root of Scutellaria indica L., together with 2(S)-5,2'-dihydroxy-7,8,6'-trimethoxyflavanone, 5,7-dihydroxy-8,2'-dimethoxy flavone, rivularin, 5,2',6'-trihydroxy-7,8-dimethoxyflavone, scutevurin, 5,7,4'-trihydroxy-8-methoxyflavone, wogonin, alpinetin, caldamomin and wogonin 7-O-glucuronide.Compounds I-V (Fig. 1) were identified based on spectral data and simple chemical modifications.Keywords--Scutellaria indica; Labiatae; flavonoid; flavone; flavanone; chalcone; structure elucidation

A New Cleavage Method for the Sugar-Aglycone Linkage in Saponin

A new cleavage method for the sugar-aglycone linkage in saponin is described.Treatment of 2)-O-α-L-arabinopyranosyl-(1->3)-β-D-glucopyranosid>uronic acid (1) with diazomethane-ether in methanol gave the aglycone 2 and the sugars 3 and 4.On the basis of chemical and spectral evidence they were determined as methyl 3β,23α-dihydroxy-3-O,23-methylenolean-12-en-28-oate (2), methyl 2)-O-α-L-arabinopyranosyl-(1->3)-α-D-glucopyranosid>uronate (3), and methyl O-β-D-galactopyranosyl-(1->2)-O-α-L-arabinopyranosyl-(1->3)-1,4-anhydro-α-D-glucopyranuronate (4).This method is useful for structure determination of some oleanane triterpenoid saponins and for yielding new oligosaccharides.The cleavage of the quillaic acid 3-O-glycoside 10 is also discussed.