196609-10-6Relevant academic research and scientific papers
High-diastereoselective and enantioselective cyclopropanation of α,β- unsaturated Fischer carbene complexes: Synthesis of chiral 1,2-disubstituted and 1,2,3-trisubstituted cyclopropanes
Barluenga,Bernad P.L.,Concellon
, p. 6870 - 6875 (1997)
Reaction of chiral vinylcarbene complexes 1 with in situ-generated iodomethyllithium or dibromomethyllithium gives cyclopropylcarbene complexes 4 and 13, respectively, with high diastereoselectivity (de > 91%). Different enantiopure 1,2-disubstituted and 1,2,3-trisubstituted cyclopropanes are obtained starting from chiral carbene complexes 4 and 13, respectively.
