19666-76-3

Usage

Uses

Used in Pharmaceutical Industry:
Panaxadiol is used as an anti-tumor agent for its ability to enhance the activity against human colorectal cancer cells. Its potential in modulating oncological signaling pathways and synergistic effects with conventional chemotherapeutic drugs can improve chemo-sensitivity and therapeutic outcomes.
Used in Drug Delivery Systems:
To optimize the delivery and bioavailability of Panaxadiol, various drug delivery systems, including organic and metallic nanoparticles, can be employed as carriers. These systems aim to enhance the therapeutic efficacy of Panaxadiol and overcome limitations associated with its use in cancer treatment.

InChI:InChI=1/C30H52O3/c1-25(2)13-9-14-30(8,33-25)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-32H,9-18H2,1-8H3

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Sensitive Determination of Panaxadiol (cas 19666-76-3) Using Rhodamine B as Sensitizing Derivatization Reagent by Ultrahigh Performance Liquid Chromatography Triple Quadrupole Mass Spectrometry09/09/2019

Commercial Rhodamine B was first reported as a derivatization reagent labeling hydroxyl compound for mass spectrometry sensitization. In virtue of the strategy of ultrasonic-assisted dispersive liquid-liquid microextraction (UA-DLLME) combined with Rhodamine B derivatization, a new method of ult...detailed

Malignant HematopoiesisThe effects of Panaxadiol (cas 19666-76-3) saponins on megakaryocytic maturation and immune function in a mouse model of immune thrombocytopenia09/08/2019

We have identified a biologically active component, panaxadiol saponins component (PDS-C), from Chinese ginseng herb extract. Panaxadiol saponins component contains five ginsenoside monomers with total purity of 92.44%. In this study, the BALB/c mouse model with immune thrombocytopenia (ITP) was...detailed

Original articleEfficient synthesis of Panaxadiol (cas 19666-76-3) derivatives using continuous-flow microreactor and evaluation of anti-tumor activity09/04/2019

An efficient method has been developed for the synthesis of a series of (20R)-panaxadiol derivatives (4a–w) using a continuous-flow microreactor. The antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines (i.e., PC-3...detailed

Original articleSynthesis and anti-tumor evaluation of Panaxadiol (cas 19666-76-3) derivatives09/02/2019

A series of panaxadiol derivatives have been synthesized by the simple acylation of the 3-hydroxy group of panaxadiol. The anti-tumor activities of the synthesized compounds were evaluated against a panel of human tumor cell lines by the standard MTT assay. Compounds 2, 11, 12, 13, 14, 15 and 16...detailed

Synthesis and anti-tumor evaluation of Panaxadiol (cas 19666-76-3) halogen-derivatives09/01/2019

In the current work, 13 novel panaxadiol (PD) derivatives were synthesized by reacting with chloroacetyl chloride and bromoacetyl bromide. Their in vitro antitumor activities were evaluated on three human tumor cell lines (HCT-116, BGC-823, SW-480) and three normal cells (human gastric epithelia...detailed

Panaxadiol (cas 19666-76-3) inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells08/31/2019

AimAlzheimer's disease (AD), a neurodegenerative disease, is characterized by memory loss and synaptic damage. Up to now, there are limited drugs to cure or delay the state of this illness. Recently, the Fyn tyrosine kinase is implicated in AD pathology triggered by synaptic damage. Thus, F...detailed