Original articleEfficient synthesis of Panaxadiol (cas 19666-76-3) derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

Add time:09/04/2019    Source:sciencedirect.com

An efficient method has been developed for the synthesis of a series of (20R)-Panaxadiol (cas 19666-76-3) derivatives (4a–w) using a continuous-flow microreactor. The antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines (i.e., PC-3 and LNCaP cells), and their cytotoxicities were evaluated using a standard MTT assay. Compounds 4c, 4h, 4p, 4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol, which was used as a reference standard.

We also recommend Trading Suppliers and Manufacturers of Panaxadiol (cas 19666-76-3). Pls Click Website Link as below: cas 19666-76-3 suppliers

Prev:Biotransformation of 20(R)-Panaxadiol (cas 19666-76-3) by the fungus Rhizopus chinensis
Next:Microbial transformation of 20(R)-Panaxadiol (cas 19666-76-3) by Absidia corymbifera AS 3.3387)