196703-95-4Relevant articles and documents
A Synthetic Bioinspired Carbohydrate Polymer with Mucoadhesive Properties
Balijepalli, Anant S.,Sabatelle, Robert C.,Chen, Mingfu,Suki, Bela,Grinstaff, Mark W.
, p. 704 - 710 (2020)
Mucoadhesive polymers are of significant interest to the pharmaceutical, medical device, and cosmetic industries. Polysaccharides possessing charged functional groups, such as chitosan, are known for mucoadhesive properties but suffer from poor chemical d
Improved and large-scale synthesis of different protected d-glucuronals
Mikula, Hannes,Matscheko, Dominik,Schwarz, Markus,Hametner, Christian,Fr?hlich, Johannes
, p. 19 - 23 (2013/04/23)
Although different protected d-glucuronals are used as precursors for the preparation of many compounds, standard procedures and large-scale syntheses are still not described in the literature. In the course of the development of different protected d-glucuronyl donors we developed several versatile methods that can be used for fast and reproducible preparation of large amounts of the key intermediates. d-Glucuronolactone was converted to methyl 3,4-di-O-acetyl-d-glucuronal applying a novel one-pot protocol, which allowed for large-scale synthesis. Introduction of silyl and benzyl groups was achieved using optimized procedures. Furthermore 3,4,6-tri-O-acetyl-d-glucal was used as starting material for an improved preparation of benzyl protected d-glucuronal, which significantly accelerates and simplifies similar methods described in the literature.
Automated Synthesis of Oligosaccharides
Palmacci, Emma R.,Plante, Obadiah J.,Hewitt, Michael C.,Seeberger, Peter H.
, p. 3975 - 3990 (2007/10/03)
The chemical synthesis of oligosaccharides with an automated solid-phase synthesizer is described. An octenediol linker served to attach the growing oligosaccharide chain to the solid support, and the desired structures were cleaved from the support via o