196708-48-2

Basic information

• Product Name: Methyl 2-chloro-4-(trifluoromethyl)nicotinate
• Synonyms: Methyl 2-chloro-4-(trifluoromethyl)nicotinate;Methyl 2-chloro-4-(trifluoromethyl)pyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-4-(trifluoromethyl)pyridine
• CAS NO: 196708-48-2
• Molecular Formula: C8H5ClF3NO2
• Molecular Weight: 239.5790096
• Mol File: 196708-48-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 2-chloro-4-(trifluoromethyl)nicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-chloro-4-(trifluoromethyl)nicotinate(196708-48-2)
• EPA Substance Registry System: Methyl 2-chloro-4-(trifluoromethyl)nicotinate(196708-48-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 196708-48-2(Hazardous Substances Data)

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 185041-05-8 2-chloro-4-iodonicotinic acid methyl ester 
• 1064678-14-3 methyl 4-bromo-2-chloronicotinate 

Relevant articles and documents

Efficient copper-catalyzed trifluoromethylation of aromatic and heteroaromatic iodides: The beneficial anchoring effect of borates

Efficient copper-catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF3 in the presence of trimethylborate. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomposition. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionalization of different aromatic and heteroaromatic iodides.

Isoxazole derivatives

An isoxazole compound having the following formula: wherein R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.