19673-06-4

Upstream product

• 108-91-8 cyclohexylamine 
• 100-47-0 benzonitrile 
• 110-83-8 cyclohexene 

Downstream Products

• 1350628-99-7 1-cyclohexyl-2-phenyl-1H-benzo[d]imidazole 
• 1450606-13-9 1-cyclohexyl-2-phenyl-4-(thiazol-2-ylamino)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-5-one 
• 1269080-54-7 4-(pyrimidin-2'-ylamino)-4-trifluoromethyl-2-phenyl-1-cyclohexyl-4,5-dihydroimidazol-5-one 
• 1321177-26-7 N-cyclohexyl-3,4-diphenylisoquinolin-1-amine 
• 74333-43-0 N₂-dipropylboryl-N₁-cyclohexylbenzamidine 
• 53205-26-8 N-cyclohexyl, N'-o-tolyl-benzamidine hydrochloride 

Relevant academic research and scientific papers

Use of Lanthanide(III) Ions as Catalysts for the Reactions of Amines with Nitriles

Catalytic amounts of lanthanide(III) triflates promote reactions between amines and nitriles leading to a variety of products.The Ln3+ ions activate weakly coordinating nitriles at large amine: Ln3+ mole ratios, even in the presence of amines that form thermodynamically stable complexes with Ln3+ ions.The reactions involving primary monoamines and diamines appear to be general and provide a viable synthetic route to N,N'-disubstituted amidines (2) and cyclic amidines (4), respectively.Symmetrically substituted triazines (8 or 9) are observed as byproducts in some of these systems when the reactions are carried out by using excess nitrile.Secondary alicyclic amines or dimethylamine reacts with acetonitrile to yield pyrimidines (6) and 2,4,6-trimethyl-s-triazine (8).Two routes to triazine have been proposed, one involving the reaction of ammonia with the nitrile and the second involving the reaction of an amidine (1 or 5) with the nitrile.The ability of Ln3+ ions to activate nitriles under conditions that oppose nitrile coordination is attributed to the lability of Ln3+ complexes derived from N-donors.

Sulfated tungstate catalyzed activation of nitriles: addition of amines to nitriles for synthesis of amidines

An efficient and mild method for the synthesis of amidines by direct nucleophilic addition of amines to nitriles using sulfated tungstate as heterogeneous catalyst is described. Highlight of the method is its applicability for the synthesis of amidines using a wide variety of amines including ammonia as ammonium acetate and nitriles. Catalyst is mildly acidic, stable, easy to prepare and separate from the reaction mass.

Charge Effects in PCP Pincer Complexes of NiII bearing Phosphinite and Imidazol(i)ophosphine Coordinating Jaws: From Synthesis to Catalysis through Bonding Analysis

This contribution reports on a new family of NiII pincer complexes featuring phosphinite and functional imidazolyl arms. The proligands RPIMCHOPR′ react at room temperature with NiII precursors to giv

Regiospecific synthesis of 1, 2-disubstituted (hetero)aryl fused imidazoles with tunable fluorescent emission

A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1, 2 disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaf

N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors

The invention described herein relates to certain pyrimidinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

Electrochemical behavior of amidine hydrochlorides and amidines

The electrochemical behavior of N,N-dimethyl-N'-phenylformamidine hydrochloride was studied on a platinum electrode.The oxidation peak at +0.90 V vs.Ag/Ag+ 0.01 M (in CH3CN - 0.1 M LiClO4) was assigned to the oxidation of the chloride anion.N,N