196799-20-9

Upstream product

• 100-39-0 benzyl bromide 
• 207401-98-7 (4S,5R,6R)-4-Acetoxy-5-acetylamino-6-((1R,2R)-1,2,3-trihydroxy-propyl)-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester 
• 25875-99-4 methyl 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonate 
• 73960-72-2 methyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate 
• 108999-10-6 Methyl 5-acetamido-2,3,5-trideoxy-8,9-O-isopropylidene-D-glycero-D-galacto-non-2-enopyranosonate 
• 207401-97-6 (4S,5R,6R)-4-Acetoxy-5-acetylamino-6-[(S)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

8-O-Sialylation of neuraminic acid acceptor reactivity and anomeric stereocontrol

2-O-unprotected and 2-deoxy-2,3-dehydro-neuraminic acid derivatives 2, 4, and 10 exhibit enhanced acceptor properties at their 8-hydroxy group in sialylation reactions with phosphite 5 as donor: yet, mainly (10) or exclusively (2, 4) β-glycoside bond formation was observed. The 3-phenylthionocarbonate group as stereodirecting auxiliary group in the sialyl donor 11 led with 10 as acceptor to exclusive formation of α(2-8)-linked disaccharide.