1968-17-8

Basic information

• Product Name: 1H-Indole, 6-methoxy-1-methyl-
• CAS NO: 1968-17-8
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol File: 1968-17-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 6-methoxy-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 6-methoxy-1-methyl-(1968-17-8)
• EPA Substance Registry System: 1H-Indole, 6-methoxy-1-methyl-(1968-17-8)

Safety Data

• Hazardous Substances Data: 1968-17-8(Hazardous Substances Data)

Usage

Molecular Structure

Bicyclic heterocyclic compound

Appearance

Pale yellow to dark brown solid

Melting Point

Approximately 76-78°C

Usage

Building block in the synthesis of pharmaceuticals, agrochemicals, and organic compounds

Potential Biological Activities

Anti-inflammatory and anticancer properties

Upstream product

• 1352622-07-1 2,4,6-trichlorophenyl 1-bromo-2-((3-methoxyphenyl)(methyl)amino)ethanesulfonate 
• 1352621-99-8 1-bromo-2-(3-methoxyphenylamino)ethanesulfonic acid 2,4,6-trichlorophenyl ester 

Downstream Products

• 202807-44-1 6-methoxy-1-methyl-1H-indole-3-carbaldehyde 

Relevant articles and documents

A selective, tin-free radical mediated synthesis of indoles based on a sulfonate template

A synthesis of indoles based on a vinyl sulfonate template is described. The approach employs a sulfonate group which plays three discrete roles in the synthetic sequence. Firstly the highly electron-withdrawing sulfonate group behaves as an activating group for a 1,4-addition of an aniline to the unsaturated system. Secondly, the electron-withdrawing nature of the same group also allows it to behave as a radical stabilising group which facilitates radical cyclisation to an aromatic ring to yield a transient indoline. Finally, the pendant sulfonate group behaves as a leaving group to yield the indole.