6-methoxy-1-methyl-1H-indole

Base Information

Chemical Name:6-methoxy-1-methyl-1H-indole
CAS No.:1968-17-8
Molecular Formula:C10H11NO
Molecular Weight:161.203
Hs Code.:
ChEMBL ID:CHEMBL1877407
DSSTox Substance ID:DTXSID50406472
Nikkaji Number:J1.155.663I
Wikidata:Q82211446
Mol file:1968-17-8.mol

Synonyms:6-methoxy-1-methyl-1H-indole;1968-17-8;6-methoxy-1-methylindole;MLS002206432;SCHEMBL1093766;CHEMBL1877407;DTXSID50406472;VTJXLVGZNOINAD-UHFFFAOYSA-N;HMS2195A05;HMS3351A20;AKOS004117108;SMR001295248

Suppliers and Price of 6-methoxy-1-methyl-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 6-methoxy-1-methyl-1H-indole

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:161.084063974
Heavy Atom Count:12
Complexity:160

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=CC2=C1C=C(C=C2)OC

Technology Process of 6-methoxy-1-methyl-1H-indole

There total 2 articles about 6-methoxy-1-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1352622-07-1
2,4,6-trichlorophenyl 1-bromo-2-((3-methoxyphenyl)(methyl)amino)ethanesulfonate

: 1968-17-8
6-methoxy-1-methyl-1H-indole

: 7556-35-6
4-methoxy-1-methyl-1H-indole

: 1352622-16-2
C₁₆H₁₆Cl₃NO₄S

Guidance literature:: With triethyl borane; oxygen; N-ethylpiperidinium hypophosphite; In 1,4-dioxane; hexane; at 73 ℃; for 2h; Air atmosphere;
DOI:10.1016/j.tetlet.2011.10.093

Reference yield:

: 1352621-99-8
1-bromo-2-(3-methoxyphenylamino)ethanesulfonic acid 2,4,6-trichlorophenyl ester

: 1968-17-8
6-methoxy-1-methyl-1H-indole

: 7556-35-6
4-methoxy-1-methyl-1H-indole

: 1352622-16-2
C₁₆H₁₆Cl₃NO₄S

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / water; acetonitrile / 12 h / 20 °C

2: triethyl borane; oxygen; N-ethylpiperidinium hypophosphite / 1,4-dioxane; hexane / 2 h / 73 °C / Air atmosphere

With triethyl borane; oxygen; sodium cyanoborohydride; acetic acid; N-ethylpiperidinium hypophosphite; In 1,4-dioxane; hexane; water; acetonitrile;
DOI:10.1016/j.tetlet.2011.10.093

Reference yield: 97.0%

: 1968-17-8
6-methoxy-1-methyl-1H-indole

: 3265-14-3
3-diazo-1-methyl-1,3-dihydro-indol-2-one

: 178425-11-1
N,N-dibenzyl-N-methoxymethylamine

: (S)-3-((dibenzylamino)methyl)-3-(6-methoxy-1-methyl-1H-indol-3-yl)-1-methylindolin-2-one

Guidance literature:: With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; 12-hydroxy-1,10-bis(2,4,6-triisopropyphenyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocine 12-oxide; In dichloromethane; at -20 ℃; enantioselective reaction; Schlenk technique; Molecular sieve; Inert atmosphere;
DOI:10.1021/acs.orglett.9b03787