196822-27-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(Trifluoromethyl)-3-pyrrolidinol Hydrochloride is used as a key intermediate in the synthesis of TRK kinase inhibitors for the treatment of pain, inflammation, neurodegenerative diseases, or cancer in mammals. Its unique structure allows for the development of targeted therapies that can effectively address these conditions.
Used in Medicinal Chemistry Research:
3-(Trifluoromethyl)-3-pyrrolidinol Hydrochloride is utilized in medicinal chemistry research to explore the potential of TRK kinase inhibitors as therapeutic agents. Its synthesis and modification can lead to the discovery of novel compounds with improved efficacy and selectivity, ultimately benefiting patients suffering from various diseases.

Upstream product

• 644970-36-5 3-hydroxy-3-trifluoromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Heterocyclic IDH mutant inhibitor, preparation method and application thereof

The invention discloses a heterocyclic IDH mutant inhibitor, a preparation method and application thereof, belongs to the field of medicines, and particularly relates to a s-triazine compound with structural characteristics of a general formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition, a preparation method of the s-triazine compound, and application of the s-triazine compound or the pharmaceutically acceptable salt and the pharmaceutical composition as isocitrate dehydrogenase 2 (IDH2) mutant inhibitors. The compound disclosed by the invention has an obvious inhibiting effect on the activity of an IDH2 mutant (mIDH2), can effectively inhibit the process of catalyzing alpha-ketoglutaric acid to generate 2-hydroxyglutaric acid by the mIDH2, and can be used for preventing and/or treating various related diseases including cancers caused by IDH2 mutation.

4 -Aminopyridine derivative, pharmaceutical composition, preparation method and application thereof

The invention discloses a 4-aminopyridine derivative, a preparation method, a pharmaceutical composition and application thereof. The 4-aminopyridine derivative (I), an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure shown in the specification. The 4-aminopyridine derivative has a good adenosine A2a receptor antagonist effect, and related diseases such as cancer, central nervous system diseases and the like caused by adenosine A2a receptor level disorder can be effectively treated or relieved.

HETEROCYCLIC COMPOUND

Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.