19686-26-1Relevant academic research and scientific papers
Biomimetic Oxidative Coupling Cyclization Enabling Rapid Construction of Isochromanoindolenines
Ye, Jinxiang,Lin, Yuqi,Liu, Qing,Xu, Dekang,Wu, Fan,Liu, Bin,Gao, Yu,Chen, Haijun
supporting information, p. 5457 - 5460 (2018/09/13)
Herein, we report a biomimetic oxidative coupling cyclization strategy for the highly efficient functionalization of tetrahydrocarbolines (THCs). This process enables rapid access to complex isochromanoindolenine scaffolds in moderate to excellent yields.
Targeting low-druggability bromodomains: Fragment based screening and inhibitor design against the BAZ2B bromodomain
Ferguson, Fleur M.,Fedorov, Oleg,Chaikuad, Apirat,Philpott, Martin,Muniz, Joao R. C.,Felletar, Ildiko,Von Delft, Frank,Heightman, Tom,Knapp, Stefan,Abell, Chris,Ciulli, Alessio
supporting information, p. 10183 - 10187 (2014/01/17)
Bromodomains are epigenetic reader domains that have recently become popular targets. In contrast to BET bromodomains, which have proven druggable, bromodomains from other regions of the phylogenetic tree have shallower pockets. We describe successful tar
