196875-58-8

Upstream product

• 932-96-7 N-methyl(p-chloroaniline) 
• 73921-19-4 5-benzoyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1374448-11-9 N-(4-chlorophenyl)-N-methyl-2-diazo-3-oxo-3-phenylpropanamide 
• 1374448-21-1 5-chloro-3-(hydroxy(phenyl)methylene)-1-methylindolin-2-one 

Relevant academic research and scientific papers

Ruthenium-catalyzed intramolecular cyclization of diazo-β-ketoanilides for the synthesis of 3-alkylideneoxindoles

With [Ru(p-cymene)Cl2]2 as catalyst, diazo-β-ketoanilides would undergo intramolecular carbenoid arene C-H bond functionalization to afford 3-alkylideneoxindoles in up to 92% yields. The reaction occurs under mild conditions and exhibits excellent chemoselectivity. The lack of primary KIE (kH/kD ～ 1) suggests that the reaction should not proceed by rate-limiting C-H bond cleavage; a mechanism involving cyclopropanation of the arene is proposed.