196880-47-4Relevant academic research and scientific papers
NOVEL LYSOPHOSPHATIDIC ACID DERIVATIVE
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Paragraph 0585-0860, (2021/05/28)
PROBLEM TO BE SOLVED: To provide a compound that specifically activates an LPA4 receptor, and a pharmaceutical composition containing the same. SOLUTION: This invention relates to a novel lysophosphatidic acid derivative that has an agonistic action on an LPA4 receptor and is useful for the prevention and/or treatment of a disease with angiodysplasia caused by the LPA4 receptor, or a disease associated with angiopathy, or symptoms associated therewith. This invention also relates to a pharmaceutical composition containing the lysophosphatidic acid derivative. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Facile deprotection of dithioacetals by using a novel 1,4-benzoquinone/cat. NaI system
Inamoto, Kiyofumi,Yamada, Tetsuya,Kato, Sei-Ichi,Kikkawa, Shoko,Kondo, Yoshinori
, p. 9192 - 9199 (2013/10/01)
The combination of 1,4-benzoquinone and a catalytic amount of NaI was found to be effective for the deprotection of dithioacetals. The reactions proceeded efficiently under mild, near-neutral reaction conditions, producing a wide range of aryl and alkyl aldehydes and ketones generally in high yields with good functional group compatibility. The method developed therefore represents a general, facile, and highly applicable approach for deprotecting dithioacetals.
A new approach to tubacin
Hong, Jian,Xu, Xin,Das, Debasis,Yang, Pengyu,Chen, Shu-Hui,Li, Ge
scheme or table, p. 50 - 53 (2010/09/04)
Tubacin, histone deacetylases, allyl borane reaction, stereoselective ketal formation, solution phase synthesis, hydroxyamide synthesis.A new simple synthesis of tubacin is reported. It entails the formation of the syn-1,3-diol unit and its stereoselective ketalization with a functionalized benzaldehyde derivative.
Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation and structure-activity relationships. Part 2
Horiuchi, Takao,Nagata, Motoko,Kitagawa, Mayumi,Akahane, Kouichi,Uoto, Kouichi
experimental part, p. 7850 - 7860 (2010/04/02)
The design, synthesis and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitor are described. Focusing on the optimization of the heteroaryl moiety at the hydrazone with substituted phenyl group
Selective oxidation of benzylic alcohols and TBDMS ethers to carbonyl compounds with CrO3-H5IO6
Zhang, Suhong,Xu, Liang,Trudell, Mark L.
, p. 1757 - 1760 (2007/10/03)
Benzyl alcohols and benzyl TBDMS ethers were efficiently oxidized to the corresponding carbonyl compounds in high yield with periodic acid catalyzed by CrO3 at low temperature (-78°C). The oxidation procedure was highly functional group tolerant and very selective for the TBDMS group over the TBDPS group. Georg Thieme Verlag Stuttgart.
Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin.
Sternson,Wong,Grozinger,Schreiber
, p. 4239 - 4242 (2007/10/03)
Seventy-two hundred potential inhibitors of the histone deacetylase (HDAC) enzyme family, based on a 1,3-dioxane diversity structure, were synthesized on polystyrene macrobeads. The compounds were arrayed for biological assays in a "one bead-one stock sol
Synthesis and Properties of First and Second Generation Chiral Dendrimers with Triply Branched Units: A Spectacular Case of Diastereoselectivity
Murer, Peter K.,Lapierre, Jean-Marc,Greiveldinger, Guy,Seebach, Dieter
, p. 1648 - 1681 (2007/10/03)
Chiral triols (which may be considered as derivatives of tris(hydroxymethyl)methane), without (3-5) and with aliphatic (6) or aromatic (7) elongating units, and the 1st- and 2nd-generation benzylic branched bromides, 17, 18, 23, 24, 29, and 30 are subject
