196882-97-0

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 98-09-9 benzenesulfonyl chloride 
• 34259-86-4 1-benzenesulfonyl-piperidin-4-one 
• 267666-13-7 1-benzenesulfonyl-4,4-dimethoxy-piperidine 

Downstream Products

• 196882-99-2 2,5-bis-benzenesulfonyl-8-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-42-2 trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester 
• 267666-36-4 2,5-bis-benzenesulfonyl-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-45-5 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-67-1 5-benzenesulfonyl-1-chloro-7,8-dimethoxy-5H-pyrido[4,3-b]indole 
• 267666-58-0 5-benzenesulfonyl-7,8-dimethoxy-5H-pyrido[4,3-b]indole 2-oxide 
• 267666-52-4 5-benzenesulfonyl-7,8-dimethoxy-5H-pyrido[4,3-b]indole 
• 267666-68-2 5-benzenesulfonyl-1-chloro-7-methoxy-5H-pyrido[4,3-b]indole 
• 267666-59-1 5-benzenesulfonyl-7-methoxy-5H-pyrido[4,3-b]indole 2-oxide 
• 267666-53-5 5-benzenesulfonyl-7-methoxy-5H-pyrido[4,3-b]indole 

Relevant academic research and scientific papers

Lewis Acid-Directed Cyclocondensation of Piperidone Enol Ethers with 2-Methoxy-4-(N-phenylsulfonyl)-1,4-benzoquinoneimine: A New Regioselective Synthesis of Oxygenated Carbolines

Lewis acid-directed cyclocondensations of piperidone enol ethers with 2-methoxy-4-(N-phenylsulfonyl)-1,4-henzoquinoneimine are reported. Benzofurans are obtained with BF3·OEt2 as a promoter, whereas use of excess amounts of TiCl4:Ti(OiPr)4 leads to tetrahydrocarbolines. The latter reactions provide expedient routes to oxygen-substituted tetrahydrocarbolines and carbolines. As applications of this new methodology, the preparations of 1-[3-(dimethylamino)propyl]amino-7-methoxy- and 1-[3-(dimethylamino)propyl]amino-7,8-dimethoxy-5H-pyrido[4,3-b]indoles are described.