196932-95-3

Upstream product

• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 636-98-6 p-nitrobenzene iodide 
• 423-39-2 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane 
• 98-95-3 nitrobenzene 
• 71-43-2 benzene 

Downstream Products

• 114262-65-6 4-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)-phenylamine 

Relevant academic research and scientific papers

A perfluoroalkyl-aromatic compound azanol and its preparation method

The invention relates to a perfluorinated alkyl aromatic hydroxylamine compound and a preparation method thereof, and belongs to the field of chemical synthesis. The perfluorinated alkyl aromatic hydroxylamine compound has a structure formula shown in the specification. The preparation method of the perfluorinated alkyl aromatic hydroxylamine compound comprises the following steps of: synthesizing by coupled reaction and reduction reaction with iodo-4-nitrobenzene and perfluoroalkanes serving as raw materials; and recrystallizing, separating and purifying. The perfluorinated alkyl aromatic hydroxylamine compound is an important intermediate of a hydroxamic acid fluorocarbon phase catalyst containing a perfluoroalkyl group chain. The aromatic hydroxylamine also serves as an important raw material or intermediate in synthesis of pesticide, medicine and chemical products; the synthesis of the perfluorinated alkyl aromatic hydroxylamine compound enables the enriching of the variety of an aromatic hydroxylamine compound.

A general, regiospecific synthetic route to perfluoroalkylated arenes via arenediazonium salts with RFCu(CH3CN) complexes

A mild method of converting arylamines into perfluoroalkylated arenes is described. Relatively stable RFCu(CH3CN) complexes are used as perfluoroalkylating agents, which react smoothly with arenediazonium salts to produce various perfluoroalkylarenes in good yields. Based on the results of clock trapping experiments with diallyl ether, a radical process might be involved in the reaction.

Bipyridinium ionic liquid-promoted cross-coupling reactions between perfluoroalkyl or pentafluorophenyl halides and aryl iodides

(Chemical Equation Presented) A new room-temperature ionic liquid has been synthesized from 2,2′-bipyridine. This liquid improved the copper-catalyzed cross-coupling reactions between perfluoroalkyl or pentafluorophenyl halides and aryl iodides. Good recyclability using this solvent system was observed.

Substituted amine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

New Methods of Free-Radical Perfluoroalkylation of Aromatics and Alkenes. Absolute Rate Constants and Partial Rate Factors for the Homolytic Aromatic Substitution by n-Perfluorobutyl Radical

New methods of free-radical perfluoroalkylation of aromatics and alkenes are reported. n-C4F9I has been utilized as source of C4F9. radical through iodine abstraction by phenyl or methyl radical. The