197015-72-8 Usage
Type of compound
Halogenated aromatic compound
Structure
Benzene ring with two methoxy groups (-OCH3) and three trifluoromethyl groups (-CF3) attached
Iodo group presence
Useful for chemical reactions (e.g. nucleophilic substitution, palladium-catalyzed coupling reactions)
Physical state
Volatile, colorless liquid
Odor
Strong
Usage
Building block in the synthesis of pharmaceutical compounds and agrochemicals
Hazard classification
Potential health and environmental risks (need proper handling and storage)
Check Digit Verification of cas no
The CAS Registry Mumber 197015-72-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,0,1 and 5 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 197015-72:
(8*1)+(7*9)+(6*7)+(5*0)+(4*1)+(3*5)+(2*7)+(1*2)=148
148 % 10 = 8
So 197015-72-8 is a valid CAS Registry Number.
197015-72-8Relevant academic research and scientific papers
A convenient synthesis of 3,5-bis(trifluoromethyl)salicylic acid
Sui, Zhihua,Macielag, Mark J.
, p. 3581 - 3590 (2007/10/03)
A convenient method is reported for the synthesis of the biologically important intermediate, 3,5-bis(trifluoromethyl)-salicylic acid, by a sequence involving diazotization/iodination of 2-bromo-3,5-bis(trifluoromethyl)aniline, displacement of the bromide with sodium methoxide, and carboxylation of the anion generated by lithium-iodine exchange with carbon dioxide. Alternatively, the anion could be carbonylated with dimethylformamide and the resulting aldehyde oxidized with Jones reagent. Demethylation of 3,5-bis(trifluoromethyl)anisic acid with boron tribromide gave the title compound.
