197022-34-7Relevant academic research and scientific papers
Nucleic acid containing 3′-C-P-N-5′ ethyl phosphonamidate ester and 2′-methoxy modifications in combination; synthesis and hybridisation properties
Fairhurst, Robin A.,Collingwood, Stephen P.,Lambert, David,Wissler, Elke
, p. 763 - 766 (2007/10/03)
The preparation of thymidine-thymidine and thymidine-5-methylcytidine dinucleosides containing a 3′-C-P-N-5′ ethyl phosphonamidate ester linkage, with defined phosphorus stereochemistry, in combination with a 2′-methoxy substituent in the lower sugar residue, is described. Incorporation of these dinucleosides into DNA oligonucleotides and the effect upon duplex stability with complimentary RNA is reported.
