187733-73-9

Basic information

• Product Name: 5'-azido-5'-deoxy-2'-O-methyl-5-methyluridine
• Synonyms: 5'-azido-5'-deoxy-2'-O-methyl-5-methyluridine
• CAS NO: 187733-73-9
• Molecular Weight: 297.271
• Mol File: 187733-73-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5'-azido-5'-deoxy-2'-O-methyl-5-methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-azido-5'-deoxy-2'-O-methyl-5-methyluridine(187733-73-9)
• EPA Substance Registry System: 5'-azido-5'-deoxy-2'-O-methyl-5-methyluridine(187733-73-9)

Safety Data

• Hazardous Substances Data: 187733-73-9(Hazardous Substances Data)

Upstream product

• 251297-03-7 3'-O-TBDMS-2'-O-methyl-5-methylUrd 
• 251296-62-5 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-O-methyl-5-methyluridine 
• 251296-64-7 3'-O-(tert-butyldimethylsilyl)-5'-chloro-5'-deoxy-2'-O-methyl-5-methyluridine 
• 133023-98-0 3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine 
• 166593-44-8 1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-methyl-β-D-ribofuranos-1-yl>thymine 
• 55486-09-4 2'-O-Methyl-5-methyluridine 
• 131132-30-4 N³-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyl disiloxane-1,3-diyl)5-methyluridine 
• 268747-99-5 5'-chloro-5'-deoxy-2'-O-methyl-5-methyluridine 
• 251296-66-9 5'-azido-3'-O-(tert-butyldimethylsilyl)-5'-deoxy-2'-O-methyl-5-methyluridine 
• 187733-72-8 1-((2R,3R,4S,5S)-4-Hydroxy-5-iodomethyl-3-methoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 187733-60-4 1-[(2R,3R,4R,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 171762-61-1 C₄₄H₄₉N₅O₁₂ 
• 187733-63-7 C₅₅H₆₇N₅O₁₀Si₂ 
• 171762-83-7 C₄₄H₄₉N₅O₁₂ 
• 171762-81-5 C₅₅H₆₇N₅O₁₀Si₂ 
• 452096-04-7 C₆₃H₇₇N₆O₁₁PSi₂ 
• 197022-33-6 C₄₅H₅₄N₅O₁₃P 
• 197022-34-7 C₄₅H₅₄N₅O₁₃P 
• 197021-58-2 N-{1-[5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 452096-06-9 1-[5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 
• 171762-85-9 4-Amino-1-[(2R,3R,4R,5R)-5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one 
• 197022-29-0 C₄₀H₅₄N₅O₁₁PSi 

Relevant articles and documents

Synthesis of amide-linked [(3')CH2CO-NH(5')] nucleoside analogues of small oligonucleotides

We report syntheses of new amide-linked (di-penta)nucleoside analogues of antisense oligonucleotide components. Solution-phase coupling of 3'- (carboxymethyl)-3'-deoxy- and 5'-amino-5'-deoxynucleoside derivatives provides amide dimers. Activated [3'-(carboxymethyl)-3'-deoxy] units with a 5'-azido-5'-deoxy function provide 'masked' 5'-amino-5'-deoxy residues for chain extension, and a 5'-O-DMT-protected unit provides the 5'-terminus for attachment to a phosphodiester linkage.

Stark erhoehte Affinitaet modifizierter Oligonucleotide mit in ihrer Konformation eingeschraenkten Furanose-Ringen fuer komplementaere RNA-Straenge

Keywords: Amide; Antisense-Oligonucleotide; Desoxyzucker; Molekular Modeling; Nucleinsaeuren