66946-81-4 Usage
Description
3-Fluoroindole is a halogenated indole compound belonging to the indole family, characterized by the presence of a pyrrole ring with a fluorine atom attached to the third carbon position. This modification of the indole ring by the fluorine atom endows 3-Fluoroindole with distinct chemical and physical properties, making it a versatile building block in organic synthesis and a promising candidate in pharmaceutical research and drug discovery.
Uses
Used in Organic Synthesis:
3-Fluoroindole is used as a building block in organic synthesis for its ability to alter the reactivity and selectivity of the indole ring. The presence of the fluorine atom influences the electronic and steric properties of the molecule, facilitating the development of novel synthetic routes and the creation of diverse chemical libraries.
Used in Pharmaceutical Research:
3-Fluoroindole is utilized as a key intermediate in the design and synthesis of new pharmaceutical agents. Its unique properties allow for the exploration of structure-activity relationships and the optimization of drug candidates with improved potency, selectivity, and pharmacokinetic profiles.
Used in Drug Discovery:
3-Fluoroindole serves as a valuable tool in drug discovery, providing a platform for the development of potential therapeutic agents. Its pharmacological activity and the ability to modulate biological targets make it an attractive starting point for the identification of novel lead compounds and the advancement of new treatments for various diseases.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-Fluoroindole is employed as a versatile scaffold for the design of bioactive molecules. Its structural modifications can lead to the discovery of new chemical entities with potential therapeutic applications, contributing to the advancement of medicinal chemistry research.
Used in Bioorganic Chemistry Research:
3-Fluoroindole is a valuable compound in bioorganic chemistry research, enabling the study of the interactions between small molecules and biological systems. Its unique properties allow for the investigation of molecular recognition, enzyme inhibition, and other biological processes, furthering our understanding of the underlying mechanisms and facilitating the development of targeted therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 66946-81-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,9,4 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 66946-81:
(7*6)+(6*6)+(5*9)+(4*4)+(3*6)+(2*8)+(1*1)=174
174 % 10 = 4
So 66946-81-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H6FN/c9-7-5-10-8-4-2-1-3-6(7)8/h1-5,10H
66946-81-4Relevant articles and documents
Compound containing indole ring structure, preparation method and application of compound, and bactericide
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Paragraph 0080; 0082; 0083; 0084, (2021/07/31)
The invention belongs to the field of pesticides and discloses a compound containing an indole ring structure, a preparation method and application of the compound and a bactericide. The compound has the structure shown in the formula (I), and the compound has an excellent prevention and treatment effect on cucumber downy mildew, is equivalent to the current commercial oomycete disease prevention and treatment agent oxathiapiprolin, and has a good market development prospect.
Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor
Yuan, Xi,Yao, Jian-Fei,Tang, Zhen-Yu
supporting information, p. 1410 - 1413 (2017/03/23)
A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li2CO3 as base at low temperature.
A synthesis of 3-fluoroindoles and 3,3-difluoroindolines by reduction of 3,3-difluoro-2-oxindoles using a borane tetrahydrofuran complex
Torres, Jose C.,Garden, Simon J.,Pinto, Angelo C.,Da Silva, Filipe S. Q.,Boechat, Nubia
, p. 1881 - 1892 (2007/10/03)
A borane tetrahydrofuran complex has been used to study the reduction of 3,3-difluoro-2-oxindoles and been found to yield either 3-fluoroindoles or 3,3-difluoroindolines. The latter have been found to be reasonably stable when the aromatic nucleus is subs
