66946-81-4

Usage

Uses

Used in Organic Synthesis:
3-Fluoroindole is used as a building block in organic synthesis for its ability to alter the reactivity and selectivity of the indole ring. The presence of the fluorine atom influences the electronic and steric properties of the molecule, facilitating the development of novel synthetic routes and the creation of diverse chemical libraries.
Used in Pharmaceutical Research:
3-Fluoroindole is utilized as a key intermediate in the design and synthesis of new pharmaceutical agents. Its unique properties allow for the exploration of structure-activity relationships and the optimization of drug candidates with improved potency, selectivity, and pharmacokinetic profiles.
Used in Drug Discovery:
3-Fluoroindole serves as a valuable tool in drug discovery, providing a platform for the development of potential therapeutic agents. Its pharmacological activity and the ability to modulate biological targets make it an attractive starting point for the identification of novel lead compounds and the advancement of new treatments for various diseases.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-Fluoroindole is employed as a versatile scaffold for the design of bioactive molecules. Its structural modifications can lead to the discovery of new chemical entities with potential therapeutic applications, contributing to the advancement of medicinal chemistry research.
Used in Bioorganic Chemistry Research:
3-Fluoroindole is a valuable compound in bioorganic chemistry research, enabling the study of the interactions between small molecules and biological systems. Its unique properties allow for the investigation of molecular recognition, enzyme inhibition, and other biological processes, furthering our understanding of the underlying mechanisms and facilitating the development of targeted therapeutic strategies.

InChI:InChI=1/C8H6FN/c9-7-5-10-8-4-2-1-3-6(7)8/h1-5,10H

Upstream product

• 197067-27-9 3,3-difluoro-1,3-dihydro-2H-indol-2-one 
• 771-50-6 1H-indole-3-carboxylic acid 
• 91-56-5 indole-2,3-dione 

Relevant academic research and scientific papers

Compound containing indole ring structure, preparation method and application of compound, and bactericide

The invention belongs to the field of pesticides and discloses a compound containing an indole ring structure, a preparation method and application of the compound and a bactericide. The compound has the structure shown in the formula (I), and the compound has an excellent prevention and treatment effect on cucumber downy mildew, is equivalent to the current commercial oomycete disease prevention and treatment agent oxathiapiprolin, and has a good market development prospect.

Electron-rich five-membered heterocyclic acid and method for decarboxylation and fluorination of derivative thereof

The invention provides electron-rich five-membered heterocyclic acid and a method for decarboxylation and fluorination of derivatives thereof. High-efficiency decarboxylation and fluorination are performed on the electron-rich five-membered heterocyclic acid with different kinds of electron-rich five-membered heterocycles connected with carboxylic acid directly, and the derivatives of the electron-rich five-membered heterocyclic acid, An obtained product has high yield and the process is simple.

Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor

A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li2CO3 as base at low temperature.

Electrosynthesis of fluorinated indole derivatives

Anodic fluorination of various N-acetyl-3-substituted indole derivatives was successfully carried out in Et4NF-4HF/MeCN to provide the corresponding trans-2,3-difluoro-2,3-dihydroindoles exclusively or selectively. Treatment of difluorinated products with a base provided monofluoroindole derivatives or monofluoroindoline derivative depending on the substituents at the 3-position.

A synthesis of 3-fluoroindoles and 3,3-difluoroindolines by reduction of 3,3-difluoro-2-oxindoles using a borane tetrahydrofuran complex

A borane tetrahydrofuran complex has been used to study the reduction of 3,3-difluoro-2-oxindoles and been found to yield either 3-fluoroindoles or 3,3-difluoroindolines. The latter have been found to be reasonably stable when the aromatic nucleus is subs