19707-16-5

Upstream product

• 634894-19-2 3β,22-dihydroxy-23,24-dinorchol-4-ene 
• 3986-89-8 (20S)-3-oxopregn-4-ene-20-carboxaldehyde 
• 40736-33-2 (20S)-20-hydroxymethylpregn-4-en-3-one 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 2140-46-7 25-hydroxychlolesterol 
• 434-16-2 7-dehydrocholesterol 

Relevant academic research and scientific papers

Methods for preparing cholesterol, and derivatives and analogs thereof

The present invention relates to the field of pharmaceutical chemistry, and in particular to methods of preparing cholesterol,and derivatives and analogs thereof. The cholesterol derivatives include, but not limited to, 7-dehydrocholesterol, 25-hydroxycholesterol, 25- hydroxy7dehydrocholesterol and ergosterol. In the invention, phytosterol can be used as a raw material to prepare the compound shown in the formula I through microbial conversion, and then cholesterol and the derivatives and analogues thereof are prepared.

Synthesis of 3β,6α-dihydroxy-5α-cholan-23-one

Evidence for the presence of 3β,6α-dihydroxy-5α -chol-9(11)-en-23-one in the aglycone mixture from the starfish Marthasterias glacialis is provided by the synthesis of 3β,6α-dihydroxy-5α -cholan-23-one (19) and its identification in the hydrogenated aglycone mixture. The side-chain is constructed from the 23,24-dinorcholanol (13) by reaction of the 22-tosylate (16) with the acetylide anion, followed by hydration of the resulting 23-yne (17).