197074-72-9Relevant academic research and scientific papers
Biphenylsulfonamide endothelin receptor antagonists. Part 3: Structure-activity relationship of 4′-heterocyclic biphenylsulfonamides
Murugesan, Natesan,Gu, Zhengxiang,Stein, Philip D.,Spergel, Steven,Bisaha, Sharon,Liu, Eddie C.-K.,Zhang, Rongan,Webb, Maria L.,Moreland, Suzanne,Barrish, Joel C.
, p. 517 - 520 (2007/10/03)
A number of 4′-heterocyclic biphenylsulfonamide derivatives, formally derived from BMS-193884 (1) by replacing the oxazole ring with other heterocyclic rings, are potent and selective endothelin A (ETA) receptor antagonists. Among the analogues examined, the pyrimidine derivative 18 is the most potent (Ki=0.9 nM) and selective for the ETA receptor, approximately equivalent to 1.
SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES
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, (2008/06/13)
Compounds of the formula STR1 inhibit the activity of endothelin. The symbols R 1, R 2, Q, K, J, α, β, p, R. sup.11, R. sup.12, R 13 R 14, X, Y, R 3 and R 4 are defined herein.
