197143-98-9

Upstream product

• 197143-95-6 Benzoic acid (2S,3R,4S,5R)-4,5-dihydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3-yl ester 
• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 98-88-4 benzoyl chloride 
• 197143-81-0 2'-trimethylsilylethyl β-D-xylopyranoside 
• 3068-31-3 1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose 
• 197143-94-5 (2S,3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3,4-diol 
• 197143-93-4 Acetic acid (2S,3R,4S,5R)-4,5-diacetoxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3-yl ester 

Downstream Products

• 880349-02-0 2-(Trimethylsilyl)ethyl 3-O-acetyl-2-O-benzoyl-4-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-β-D-xylopyranoside 

Relevant academic research and scientific papers

Antiproliferative Compositions Comprising Aryl Substituted Xylopyranoside Derivatives

Novel xylose based glycoside compounds that have xylose linked O-, S- or C-glycosidically to an aglycone containing several aromatic rings, and compositions that comprise the novel xylose based glycosides and non-xylose-based anti-tumor agents, pharmaceut

Synthesis of XylβCer, Galβ1-4XylβCer, NeuAcα2-3Galβ1-4XylβCer and the Corresponding Lactone and Lactam Trisaccharides

2-(Trimethylsilyl)ethyl 2-O-benzoyl- and 2,3-di-O-acetyl-β-D-xylopyranosides (12 and 14) were synthesized in high yields and subjected to glycosylation with various glycosyl donors. Galactosylation of 12 gave the xylose analogue of TMSEt lactoside (3), which was transformed into the glycosyl acceptor 19. Sialylation then gave the xylose analogue of GM3 trisaccharide (5). The TMSEt glycosides 10, 25, and 32 were transformed into the corresponding trichloroacetimidates, which were used for glycosylation of an azidosphingosine derivative. The resulting sphingosyl glycosides were transformed into the title ceramides. Treatment of NeuAcα2-3Galβ1-4XylβCer (5) with acetic acid gave the corresponding 1″→2′-lactone 7. Glycosylation of 12 or 14 with a GM4-lactam donor (40) gave the xylose analogue of GM3-lactam (42). There was a 3-fold increase in the formation of GAG chains in the presence of 0.5 μM XylβCer (2) in the medium.