197151-08-9

Upstream product

• 106-96-7 propargyl bromide 
• 197151-05-6 6-O-(2-Nitrophenyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 1053577-35-7 6-(2-Nitro-phenoxy)-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-trimethylsilanyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-ylamine 
• 118-00-3 G 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 69304-44-5 3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine 

Downstream Products

• 197151-13-6 2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-propargyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 

Relevant academic research and scientific papers

Protection of the guanine residue during synthesis of 2'-O-alkyl-guanosine derivatives

Highly selective 2'-O-alkylation of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine has been achieved by using an alkyl halide and a sterically hindered strong organic base, when the 6-O atom is protected with either a 2-nitrophenyl or a tert-butyldiphenylsilyl group prior to the alkylation.A minimum of chromatography is required, the yields are high and none of the unwanted isomer is produced.Moreover, the highly versatile intermediates enable the synthesis of several new 2'-O-alkylguanosine derivatives as well as base-modified analogues.