197155-57-0Relevant academic research and scientific papers
Mechanism-Based Design of an Amide-Directed Ni-Catalyzed Arylboration of Cyclopentene Derivatives
Lambright, Alison L.,Liu, Yanyao,Joyner, Isaac A.,Logan, Kaitlyn M.,Brown, M. Kevin
, p. 612 - 616 (2021/01/26)
A method for amide-directed Ni-catalyzed diastereoselective arylboration of cyclopentenes is disclosed. The reaction allows for the synthesis of sterically congested cyclopentane scaffolds that contain an easily derivatized boronic ester and amide functional handles. The nature of the amide directing group and its influence on the reaction outcome are investigated and ultimately reflect a predictably selective reaction based on the solvent and base counterion.
Synthesis of substituted cycloalkene-1,1-dicarboxylates via olefin metathesis in water
Tenbrink, Katharina,Kemker, Isabell,Schatz, Jürgen,Gr?ger, Harald
, p. 10 - 19 (2015/02/19)
A range of substituted cycloalkene-1,1-dicarboxylates was synthesized through olefin metathesis starting from readily available acylic malonate precursors in an efficient fashion. As a metathesis catalyst, a Grubbs II-type catalyst was used in these exper
Rendering schrock-type molybdenum alkylidene complexes air stable: User-friendly precatalysts for alkene metathesis
Heppekausen, Johannes,Fuerstner, Alois
supporting information; experimental part, p. 7829 - 7832 (2011/10/05)
A matter of convenience: Schrock molybdenum alkylidenes are amongst the most powerful olefin metathesis catalysts known to date, but their sensitivity to air and moisture mandates their handling in a glove-box or by Schlenk techniques. This inconvenience is circumvented by using the corresponding phenanthroline- or bipyridine adducts, which are bench-stable and hence very user-friendly. The active species can be liberated from these precatalysts in uncompromised form on treatment with ZnCl2 in toluene (see scheme).
Ruthenium-catalyzed tandem olefin metathesis-oxidations
Scholte, Andrew A.,Mi, Hyun An,Snapper, Marc L.
, p. 4759 - 4762 (2007/10/03)
(Chemical Equation Presented) The utility of Grubbs' 2nd generation metathesis catalyst has been expanded by the development of two tandem olefin metathesis/oxidation protocols. These ruthenium-catalyzed processes provide cis-diols or α-hydroxy ketones from simple olefinic starting materials.
Effects of Olefin Substitution on the Ring-Closing Metathesis of Dienes
Kirkland, Thomas A.,Grubbs, Robert H.
, p. 7310 - 7318 (2007/10/03)
Ruthenium alkylidene 1 and molybdenum alkylidene 2 have been utilized in the ring-closing metathesis (RCM) of dienes containing gem-disubstituted olefins to yield tri- and tetrasubstituted cyclic olefins. Dienes with sterically demanding and/or electron-withdrawing substituents such as Ph, CO2Me, and tBu were cyclized successfully with 2, but did not cyclize with 1. Tetrasubstituted cyclic olefins could be formed with 2, but not using alkylidene 1. Dienes with allylic functional groups yielded functionalized cyclic olefins when treated with 1.
