19716-60-0

Usage

Uses

Used in Pharmaceutical Industry:
Oxyepiberberine is used as an antimicrobial agent for its potent activity against various pathogens, making it a valuable component in the development of new antibiotics to combat drug-resistant infections.
Oxyepiberberine is used as an antitumor agent for its demonstrated efficacy in inhibiting the growth and progression of various types of cancer, offering a potential alternative or adjunct to conventional cancer therapies.
Used in Anti-inflammatory Applications:
Oxyepiberberine is used as an anti-inflammatory agent due to its potential to modulate inflammatory responses, which could be beneficial in the treatment of various inflammatory conditions.
Used in Lipid Metabolism Regulation:
Oxyepiberberine is used as a modulator of lipid metabolism, potentially contributing to the management of dyslipidemia and related metabolic disorders by regulating lipid profiles.
Used in Drug Development Research:
Oxyepiberberine is used as a target for further research in drug development, given its diverse biological activities and unique chemical structure, which may lead to the discovery of new therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 131543-46-9 Glyoxal 
• 1095272-10-8 N-(benzo[d][1,3]dioxol-4-ylmethyl)-2-(3,4-dimethoxyphen-yl)-ethan-1-amine 
• 7797-83-3 2H-benzo[d]1,3-dioxolane-4-carbaldehyde 
• 72744-54-8 5-bromo-benzo[1,3]dioxole-4-carbaldehyde 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 51665-52-2 6,7-dimethoxy-2-(5-methoxy-benzo[1,3]dioxole-4-carbonyl)-1-methylene-1,2,3,4-tetrahydro-isoquinoline 

Downstream Products

• 6873-09-2 Epiberberine 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING NASH, NAFLD, AND OBESITY

The present technology relates to methods of treating NASH, NAFLD and/or obesity using compounds of Formulas I, II, III, IV, V, and/or VI. The methods include administering to a subject suffering from one or more of non-alcoholic steatohepatitis (NASH), non- alcoholic fatty liver disease (NAFLD) and/or obesity a therapeutically effective amount of such a compound

A General, Concise Strategy that Enables Collective Total Syntheses of over 50 Protoberberine and Five Aporhoeadane Alkaloids within Four to Eight Steps

A concise, catalytic, and general strategy that allowed efficient total syntheses of 22 natural 13-methylprotoberberines within four steps for each molecule is reported. This synthesis represents the most efficient and shortest route to date, featuring three catalytic processes: CuI-catalyzed redox-A3 reaction, Pd-catalyzed reductive carbocyclization, and PtO2-catalyzed hydrogenation. Importantly, this new strategy to the tetracyclic framework has also been applied to the collective concise syntheses of >30 natural protoberberines (without 13-methyl group) and five aporhoeadane alkaloids.

Compounds and Compositions for Modulating Lipid Levels and Methods of Preparing Same

The present technology relates to compounds of Formulas I-VI and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also increase HDL-C, lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated protein kinase.

COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING LIPID LEVELS

Compositions comprising extracts or isolated or purified compounds from plants of the genus Corydalis provide prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Corydalis compounds and their derivatives of natural and synthetic origins lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression and activate AMP-activated protein kinase. Specific stereoisomers of Corydalis compounds with lipid lowering activity include 14R-(+)-corypalmine, 14R,13S-(+)-corydaline, 14R-(+)-tetrahydropalmatin, (+)-corlumidin, d-(+)-bicuculline, and (+)-egenine.