197172-43-3

Upstream product

• 130317-28-1 benzyl 2R-trifluoromethanesulfonyloxy-4-methylvalerate 
• 197172-40-0 (3S,4S)-4-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-3-hydroxy-azetidin-2-one 
• 37755-48-9 benzyl (R)-2-hydroxy-4-methylpentanoate 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 
• 328-38-1 (R)-leucine 
• 114645-19-1 [(3S,4S)-N-tert-Butoxycarbonyl-L-isoleucyl]diazomethane 

Downstream Products

• 197172-45-5 (S)-2-(N'-tert-Butoxycarbonyl-N-{(S)-2-[(2S,3S)-2-((S)-sec-butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoyl}-hydrazino)-4-methyl-pentanoic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of 3-alkoxyazetidin-2-ones: Dipeptide mimics

Several dipeptide mimics, 3-alkoxyazetidin-2-ones, were prepared in a diastereoselective fashion by the direct displacement of a scalemic triflate with 3-hydroxyazetidin-2-ones. The scope and limitation are presented.

The development of hydrazide γ-Turn mimetics

Monte Carlo calculations show a classical γ-turn in a family of metabolites known as the malformins. This led to the synthesis of epimeric seven-membered ring γ-turn mimetics starting from leucine. NMR temperature coefficient studies were also performed.