197227-96-6

Upstream product

• 121289-23-4 p-methoxybenzyloxyacetaldehyde 
• 197227-70-6 (2E)-4-[(4-methoxybenzyl)oxy]-2-methylbut-2-enal 
• 147438-56-0 (E)-(S)-1-Hydroxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-3-one 

Downstream Products

• 197227-98-8 (E)-(2S,3R)-1-(tert-Butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-3-ol 
• 147438-61-7 (E)-(3S,4S,5R)-3-Hydroxy-5-methoxy-8-(4-methoxy-benzyloxy)-4,6-dimethyl-oct-6-enoic acid methoxy-methyl-amide 
• 147438-52-6 (2E,9E)-(4S,6S,7R,8R)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-8-methoxy-11-(4-methoxy-benzyloxy)-3,7,9-trimethyl-undeca-2,9-dienal 
• 197228-05-0 2,2-Dimethyl-propionic acid (E)-(3S,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-8-(4-methoxy-benzyloxy)-4,6-dimethyl-oct-6-enyl ester 

Relevant academic research and scientific papers

Total synthesis of rhizoxin D

The convergent, enantiocontrolled synthesis of a significant antimitotic agent for cancer chemotherapy is presented with completion of rhizoxin diene 2.

The first total synthesis of the antitumor macrolide rhizoxin: Synthesis of the key building blocks

The construction in optically pure form of the key building blocks, arising from our retro synthetic analysis of the antitumor macrolide rhizoxin is described.