197227-70-6

Upstream product

• 24720-64-7 2-(triphenylphosphoranylidene)propionaldehyde 
• 121289-23-4 p-methoxybenzyloxyacetaldehyde 
• 207120-79-4 1-methoxy-4-(3-methyl-but-2-enyloxymethyl)-benzene 
• 114809-55-1 1,4-bis<(4-methoxybenzyl)oxy>but-2-ene 
• 2746-25-0 p-Methoxybenzyl bromide 
• 179548-99-3 (Z)-1,4-bis((4-methoxybenzyl)oxy)but-2-ene 
• 824-94-2 p-methoxybenzyl chloride 
• 329188-96-7 1-({[(2E)-4,4-dimethoxy-3-methylbut-2-en-1-yl]oxy}methyl)-4-methoxybenzene 

Downstream Products

• 691869-33-7 (R)-4-Benzyl-3-[(E)-(2R,3R)-3-hydroxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoyl]-oxazolidin-2-one 
• 916604-37-0 (1S,3R,4S,5E)-4-hydroxy-7-[(4-methoxybenzyl)oxy]-1,3,5-trimethyl-2-oxohept-5-en-1-yl benzoate 
• 329189-00-6 (2E,9E)-(4S,6S,7R,8R)-6-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-11-(4-methoxy-benzyloxy)-4-(2-methoxy-ethoxymethoxy)-3,7,9-trimethyl-undeca-2,9-dienal 
• 329188-98-9 (2E,9E,8S,4R,5R)-4-methoxy-8-[(2-methoxyethoxy)methoxy]-1-[(4-methoxyphenyl)methoxy]-3,5,9-trimethyl-11-(1,1,2,2-tetramethyl-1-silapropoxy)undeca-2,9-dien-6-one 
• 329188-97-8 (2E,9E)-(4R,5R,8S)-8,11-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1-(4-methoxy-benzyloxy)-3,5,9-trimethyl-undeca-2,9-dien-6-one 
• 1026332-49-9 (2E,9E,5S,6S,8S,4R)-4-methoxy-8-[(2-methoxyethoxy)methoxy]-1-[(4-methoxyphenyl)methoxy]-3,5,9-trimethyl-11-(1,1,2,2-tetramethyl-1-silapropoxy)undeca-2,9-dien-6-ol 
• 329188-99-0 1-[(2E,9E)-(4R,5R,6S,8S)-6,11-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-8-(2-methoxy-ethoxymethoxy)-3,5,9-trimethyl-undeca-2,9-dienyloxymethyl]-4-methoxy-benzene 
• 1256556-09-8 C₁₉H₂₈O₃ 
• 1283713-43-8 (3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol 
• 1283713-72-3 ((3S,4S,E)-4-tert-butyldimethylsilyloxy-7-(4-methoxybenzyloxy)-3,5-dimethylhept-5-en-1-ynyl)trimethylsilane 
• 1283713-73-4 C₂₃H₃₅IO₃Si 
• 1283713-44-9 1-(((2E,4S,5S,6Z)-4-tert-butyldimethylsilyloxy-7-iodo-3,5-dimethylhepta-2,6-dienyloxy)methyl)-4-methoxybenzene 

Relevant academic research and scientific papers

Synthesis of the C(18)-C(34) fragment of amphidinolide C and the C(18)-C(29) fragment of amphidinolide F

A convergent synthesis of the C(18)-C(34) fragment of amphidinolide C and the C(18)-C(29) fragment of amphidinolide F is reported. The approach involves the synthesis of the common intermediate tetrahydrofuranyl-β- ketophosphonate via cross metathesis, Pd

Process for total synthesis of pladienolide B and pladienolide D

[Problems to be Solved] To provide an effective process for total synthesis of pladienolide B and pladienolide D having excellent anti-tumor activity and to provide useful intermediates in the above-described process. [Measure for Solving the Problem] A process for producing a compound represented by Formula (11): wherein P1, P7, P8, P9 and R1 are the same as defined below, characterized by including reacting a compound represented by Formula (12): wherein P7 means a hydrogen atom or a protecting group for hydroxy group; R1 means a hydrogen atom or a hydroxy group, with a compound represented by Formula (13): wherein P1 means a hydrogen atom or a protecting group for hydroxy group; P8 means a hydrogen atom, an acetyl group or a protecting group for hydroxy group; P9 means a hydrogen atom or a protecting group for hydroxy group; or P8 and P9 may form together a group represented by a formula: wherein R5 means a phenyl group which may have a substituent, in the presence of a catalyst.

Total synthesis of the potent antitumor macrolides pladienolide B and D

Getting cross: The total syntheses of two pladienolides (see picture), which have prominent antitumor activity based on a unique mechanism of action, have been accomplished, and their absolute configurations were verified. The 12-membered aliphatic macrolide structure was formed by ring-closing metathesis, and the side-chain moiety was coupled to the macrolide by Julia-Kocienski olefination or cross-metathesis. (Chemical Equation Presented).

Structure assignment of lagunapyrone B by fluorous mixture synthesis of four candidate stereoisomers

Techniques of fluorous mixture synthesis have been used to make four candidate stereoisomers for the natural product lagunapyrone B. A quasiracemic mixture of vinyl iodides whose component configurations at C19-21 were encoded by fluorous silyl groups was