197240-22-5Relevant academic research and scientific papers
Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors
Puig, Carles,Miralpeix, Montserrat,Puig, Jaume,Beleta, Jordi,Huerta, Josep M.,López, Manel,Segarra, Victor,Ryder, Hamish,Palacios, José M.,Crespo, María I.,Godessart, Núria,Feixas, Joan,Ibarzo, Javier,Jiménez, Juan-Miguel,Soca, Lídia,Cardelús, Ignasi,Heredia, Ascensión
, p. 214 - 223 (2007/10/03)
A series of 3,4-diaryloxazolones were prepared and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). Extensive structure-activity relationship work was carried out within this series, and a number of potent and selective COX-2 inhibitors we
2-(3H)-OXAZOLONE DERIVATIVES AND THEIR USE AS COX-2 INHIBITORS
-
, (2008/06/13)
The invention relates to 2-(3H)-oxazolone derivatives. They may be used as COX-2 inhibitors. The compounds may be used in the treatment of colorectal cancer.
3,4-diaryloxazolone derivatives, their methods of preparation and their uses in therapeutics
-
, (2008/06/13)
The present invention relates to the derivatives of formula: STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
