197302-50-4Relevant academic research and scientific papers
Synthesis of bis(carbamoyl ester) derivatives of D-glucose as antifungal products
Len, Christophe,Postel, Denis,Ronco, Gino,Villa, Pierre
, p. 1029 - 1049 (2007/10/03)
Regiospecific carbamoylation of di-O-isopropylidene protected D-glucose gave a series of carbamoyl, thiocarbamoyl and dithiocarbamoyl esters at the C-3 secondary site. These were partially and fully deprotected to give two series of derivatives such that a choice of the extent of hydrophilic character could be made. The partially protected products were further derivatized regioselectively with a second carbamoyl, thiocarbamoyl or dithiocarbamoyl group at the C-6 primary site. We also report on antifungal properties of some of those compounds.
