19731-02-3

Basic information

• Product Name: (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID HYDRAZIDE
• Synonyms: 1H-Benzimidazole-2-aceticacid,hydrazide(9CI);2-(1H-benzimidazol-2-yl)acetohydrazide
• CAS NO: 19731-02-3
• Molecular Formula: C₉H₁₀N₄O
• Molecular Weight: 190.20625
• Product Categories: BENZIMIDAZOLE
• Mol File: 19731-02-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 204-205 °C
• Boiling Point: 574°Cat760mmHg
• Flash Point: 300.9°C
• Appearance: /
• Density: 1.383g/cm³
• Vapor Pressure: 3.51E-13mmHg at 25°C
• Refractive Index: 1.702
• PKA: 11.53±0.10(Predicted)
• CAS DataBase Reference: (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID HYDRAZIDE(19731-02-3)
• EPA Substance Registry System: (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID HYDRAZIDE(19731-02-3)

Safety Data

• Hazardous Substances Data: 19731-02-3(Hazardous Substances Data)

Usage

Uses

2-(1H-1,3-Benzodiazol-2-yl)acetohydrazide is used in the preparation of new benzimidazoles derivatives with anthelmintic properties.

InChI:InChI=1/C9H10N4O/c10-13-9(14)5-8-11-6-3-1-2-4-7(6)12-8/h1-4H,5,10H2,(H,11,12)(H,13,14)

Upstream product

• 14741-71-0 ethyl (1H-benzimidazol-2-yl)acetate 
• 13570-08-6 (1H-benzimidazol-2-yl)acetic acid 
• 4414-88-4 1H-benzimidazol-2-acetonitrile 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

The uses of ethyl 2-(1H-benzo[D]imidazol-2-yl)acetate to synthesis pyrazole, thiophene, pyridine and coumarin derivatives with antitumor activities

In the present work, the ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate (3) was subjected to a series of heterocyclization reactions through its reaction with different chemical reagents. The resulting molecules were thiophene, pyrazole, coumarin derivatives incorporated benzo[d]imidazole moiety. All the synthesized compounds were determined by elemental analysis, 1H NMR, 13C NMR, and MS. The antitumor evaluations of the newly synthesized products toward the three cancer cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) showed that compounds 5a, 9b, 9c, 17, 23b and 38 were of the highest potencies among the synthesized compounds.

SUBSTITUTED HYDRAZIDE COMPOUNDS AND APPLICATION THEREOF

The invention relates to substituted hydrazide compounds as shown by general formula I, including geometrical isomers, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, and use of the same, wherein the substitutents Ar and R having the same meanings as given in the Description. T The invention further relates to the use of compounds of general formula I in the preparation of medicament for the treatment and/or prevention of cancer and other proliferative diseases.

Syntheses and in vitro antimicrobial evaluation of some benzimidazol-2-ylmethylthioureas, benzimidazol-2-ylacetylthiosemicarbazides and products of their condensation with monochloroacetic acid

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