19731-02-3

Usage

Uses

Used in Pharmaceutical Industry:
(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID HYDRAZIDE is used as a chemical intermediate for the synthesis of new benzimidazole derivatives with anthelmintic properties. These derivatives have potential applications in the development of drugs to treat parasitic infections, particularly those caused by helminths.
Used in Chemical Research:
(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID HYDRAZIDE is also used as a research compound in various chemical studies. Its unique structure allows scientists to explore its potential in the synthesis of other organic compounds and to investigate its chemical properties and reactivity.

InChI:InChI=1/C9H10N4O/c10-13-9(14)5-8-11-6-3-1-2-4-7(6)12-8/h1-4H,5,10H2,(H,11,12)(H,13,14)

Upstream product

• 14741-71-0 ethyl (1H-benzimidazol-2-yl)acetate 
• 13570-08-6 (1H-benzimidazol-2-yl)acetic acid 
• 4414-88-4 1H-benzimidazol-2-acetonitrile 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 78439-54-0 (1H-Benzoimidazol-2-yl)-acetic acid [1-(2,3,4-trihydroxy-phenyl)-eth-(Z)-ylidene]-hydrazide 
• 78439-53-9 (1H-Benzoimidazol-2-yl)-acetic acid [1-(3-hydroxy-phenyl)-eth-(Z)-ylidene]-hydrazide 
• 78439-52-8 (1H-Benzoimidazol-2-yl)-acetic acid [1-(2-hydroxy-phenyl)-eth-(Z)-ylidene]-hydrazide 
• 126172-13-2 C₁₇H₁₇N₅OS 
• 108784-75-4 N-benzimidazol-2-ylacetyl-N'-hydrazine 
• 108784-76-5 C₁₆H₁₄ClN₅OS 
• 78439-57-3 (1H-Benzoimidazol-2-yl)-acetic acid [1-(2-amino-5-chloro-phenyl)-1-phenyl-meth-(Z)-ylidene]-hydrazide 
• 78439-51-7 (1H-Benzoimidazol-2-yl)-acetic acid [1-phenyl-eth-(Z)-ylidene]-hydrazide 
• 78772-38-0 C₁₆H₁₄ClN₅OS 
• 78439-56-2 (1H-Benzoimidazol-2-yl)-acetic acid [1-(4-hydroxy-3-methoxy-phenyl)-eth-(Z)-ylidene]-hydrazide 
• 78772-40-4 N-benzimidazol-2-ylacetyl-N'-hydrazine 
• 78772-33-5 C₁₇H₁₇N₅OS 
• 78772-34-6 C₁₇H₁₇N₅OS 
• 108784-77-6 C₁₆H₁₄BrN₅OS 

Relevant academic research and scientific papers

The uses of ethyl 2-(1H-benzo[D]imidazol-2-yl)acetate to synthesis pyrazole, thiophene, pyridine and coumarin derivatives with antitumor activities

In the present work, the ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate (3) was subjected to a series of heterocyclization reactions through its reaction with different chemical reagents. The resulting molecules were thiophene, pyrazole, coumarin derivatives incorporated benzo[d]imidazole moiety. All the synthesized compounds were determined by elemental analysis, 1H NMR, 13C NMR, and MS. The antitumor evaluations of the newly synthesized products toward the three cancer cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) showed that compounds 5a, 9b, 9c, 17, 23b and 38 were of the highest potencies among the synthesized compounds.

Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors

The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied. Compounds 7a specifically inhibit EGFR and erbB2 receptor at 0.081 and 0.098 μM concentration. Some of the compounds showed strong, broad-spectrum antiproliferative activitiy when tested against five human cancer cell lines. Compounds 7a and 7n were more cytotoxic than 5-fluorouracil against MCF-7 cancer cell, with IC50values of 5.0 and 2.55 μM whereas, only 7a led to cell cycle arrest at G2/M phase accompanied by an increase in apoptosis. Compounds 7a and 7n showed normal architecture of myofibrils in cardiomyopathy study whereas only compound 7a showed nearly equal biochemical parameters (SGOT and SGPT) when compared to control. Molecular docking & 3D-QSAR studies were used to establish interactions of 7a and 7n within the active site of enzyme for ATP binding site of kinase domain.

SUBSTITUTED HYDRAZIDE COMPOUNDS AND APPLICATION THEREOF

The invention relates to substituted hydrazide compounds as shown by general formula I, including geometrical isomers, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, and use of the same, wherein the substitutents Ar and R having the same meanings as given in the Description. T The invention further relates to the use of compounds of general formula I in the preparation of medicament for the treatment and/or prevention of cancer and other proliferative diseases.

SUBSTITUTED HYDRAZIDE COMPOUNDS AND USE THEREOF

The invention relates to substituted hydrazide compounds as shown by general formula I, including geometrical isomers, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, and use of the same, wherein the substitutents Ar and R have the same meanings as given in the Description. The invention further relates to the use of compounds of general formula I in the preparation of medicament for the treatment and/or prevention of cancer and other proliferative diseases.