19732-64-0Relevant academic research and scientific papers
Copper and palladium-catalyzed sequential reactions: One-pot synthesis of isoindolo[2,1-b] isoquinolin-7(5 H)-ones
Saini, Hitesh Kumar,Dhiman, Shiv,Nandwana, Nitesh Kumar,Krishnan, Rangan,Kumar, Anil
, p. 4281 - 4290 (2019)
A highly efficient protocol has been developed for the synthesis of diversely substituted isoindolo[2,1-b]isoquinolin-7(5H)-ones through sequential Cu(ii)-catalyzed Sonogashira coupling, intramolecular hydroamidation followed by palladium-catalyzed ligand-free Heck reaction. Good to excellent yields (41-94%) were observed with excellent substrate scope and functional group tolerance. The developed method represents a practical strategy for the construction of bioactive isoindolo[2,1-b]isoquinolin-7(5H)-ones.
