1973485-26-5Relevant articles and documents
METHOD FOR PREPARING SUBSTITUTED IMIDAZO[1,2-A]PYRIDIN-2-YLAMIDE COMPOUND, AND INTERMEDIATE THEREOF
-
, (2022/02/24)
A method for preparing a substituted imidazo[1,2-a]pyridin-2-ylamide compound and an intermediate thereof. Specifically disclosed is a method for preparing a compound represented by formula I: R1 is C1-C6 alkyl or C3-C8 cycloalkyl; R2 and R3 are independently selected from halogen and C1-C6 alkyl; R4 is Br, I or OTf, preferably being Br; and m and n are each independently 0, 1, 2, 3, or 4. The preparation method for synthesizing the compound represented by formula I features simple operation, easy control of product quality, and a high yield and is suitable for industrial production.
SALT FORM AND CRYSTAL FORM OF JAK INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
-
, (2022/02/24)
Provided in the present invention are a salt form and a crystal form of a JAK inhibitor, a preparation method therefor, and the use thereof. An X-ray powder diffraction pattern of a crystal form A of a compound as shown in formula I has characteristic diffraction peaks at the 2θ angles of 5.9°±0.2°, 7.4°±0.2°, 11.6°±0.2°, 21.7°±0.2° and 23.8°±0.2°.
SUBSTITUTED IMIDAZO [1, 2-A] PYRIDIN-2-YLAMINE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
-
, (2016/08/23)
Provided herein are substituted imidazo [1, 2-a] pyridin-2-ylamine compounds, for example, of formula (A), and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a Janus kinase-m