1973485-26-5

Basic information

• Product Name: N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide
• CAS NO: 1973485-26-5
• Molecular Weight: 280.124
• Mol File: 1973485-26-5.mol

Chemical Properties

• CAS DataBase Reference: N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide(1973485-26-5)
• EPA Substance Registry System: N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide(1973485-26-5)

Safety Data

• Hazardous Substances Data: 1973485-26-5(Hazardous Substances Data)

Upstream product

• 1026201-52-4 5-bromoimidazo[1,2-a]pyridine-2-carboxylic acid 
• 1935349-92-0 5-bromoimidazo[1,2-a]pyridin-2-ylaminocarboxylic acid tert-butyl ester 
• 1350738-82-7 5-bromoimidazo[1,2-a]pyridine-2-amine 
• 4023-34-1 cyclopropanecarboxylic acid chloride 

Relevant articles and documents

METHOD FOR PREPARING SUBSTITUTED IMIDAZO[1,2-A]PYRIDIN-2-YLAMIDE COMPOUND, AND INTERMEDIATE THEREOF

A method for preparing a substituted imidazo[1,2-a]pyridin-2-ylamide compound and an intermediate thereof. Specifically disclosed is a method for preparing a compound represented by formula I: R1 is C1-C6 alkyl or C3-C8 cycloalkyl; R2 and R3 are independently selected from halogen and C1-C6 alkyl; R4 is Br, I or OTf, preferably being Br; and m and n are each independently 0, 1, 2, 3, or 4. The preparation method for synthesizing the compound represented by formula I features simple operation, easy control of product quality, and a high yield and is suitable for industrial production.

SALT FORM AND CRYSTAL FORM OF JAK INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF

Provided in the present invention are a salt form and a crystal form of a JAK inhibitor, a preparation method therefor, and the use thereof. An X-ray powder diffraction pattern of a crystal form A of a compound as shown in formula I has characteristic diffraction peaks at the 2θ angles of 5.9°±0.2°, 7.4°±0.2°, 11.6°±0.2°, 21.7°±0.2° and 23.8°±0.2°.

SUBSTITUTED IMIDAZO [1, 2-A] PYRIDIN-2-YLAMINE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Provided herein are substituted imidazo [1, 2-a] pyridin-2-ylamine compounds, for example, of formula (A), and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a Janus kinase-m