197364-64-0

Upstream product

• 100537-61-9 2-((4-nitrophenoxy)methyl)benzothiazole 
• 37859-43-1 2-chloromethylbenzothiazole 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 197360-17-1 Methyl N-[4-(Benzothiazol-2-ylmethoxy)phenyl]thiocarbamate 
• 197359-94-7 methyl N-[4-(benzothiazol-2-ylmethoxy)phenyl]carbamate 
• 197359-95-8 Ethyl N-(4-[benzothiazol-2-ylmethoxy)phenyl]carbamate 

Relevant academic research and scientific papers

Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

A series of derivatives of the potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor diflapolin was designed, synthesized, and characterized by 1H NMR, 13C NMR, and elemental analysis. These novel compounds were biologically evaluated for their inhibitory activity against sEH and FLAP. Molecular modeling tools were applied to analyze structure-activity relationships (SAR) on both targets. Results show that even small modifications on the lead compound diflapolin markedly influence the inhibitory potential, especially on FLAP, suggesting very narrow SAR.

Aniline derivatives having herbicidal activity, their preparation and their use

Compounds of formula (I): STR1 (wherein: R1 is optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, or optionally substituted alkylthio; R2 is hydrogen, optionally substituted alkyl, cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl or a group of formula --YR7 ; R3 is optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy group, optionally substituted alkenyl, optionally substituted alkynyl, halogen, nitro or a group of formula --COR8, wherein R8 is hydrogen, alkyl, cycloalkyl or alkoxy; R4 and R5 are each hydrogen atom or alkyl; R6 is optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy group, optionally substituted alkenyl, optionally substituted alkynyl, halogen, nitro, or a group of formula --COR8, as defined above; A, Q and X are each oxygen or sulfur; Y is a group of formula --CO--, --COO--, --CH2 O--, --CH2 S--, --CH2 CH2 O--, --CH2 CH2 S--, --CH2 CO--, --CH2 COO--, --CH(Me)COO--, --CH2 CH2 CO--, --CH2 OCO--, CH2 OCOO-- and --CH2 CH2 OCO--; R7 is optionally substituted alkyl group, cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted aralkyl, or an optionally substituted heterocycle; and m and n are each an integer from 0 to 4; and herbicidally acceptable addition salts thereof) are useful as herbicides.