197379-83-2

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 197379-84-3 4-[L-alanylamino]iodobenzene 
• 1072115-68-4 C₄₅H₄₂N₆O₆ 
• 780766-93-0 1-[4-[L-alanylamino]phenyl]-2-[trimethylsilyl]acetylene 
• 780766-92-9 4-[L-alanylamino]phenylacetylene 

Relevant academic research and scientific papers

Synthesis of some 2,2′:6′,2″-terpyridines disubstituted in positions 6 and 6″ with head-to-tail oriented amino acids and dipeptides: A simple entry to a reversible inducer of folding in amino acid sequences

The 2,2′:6′,2″-terpyridine scaffold has been identified as a conformationally discrete structural element potentially capable of inducing reversible folding in substituents, attached through suitable spacers to its 6,6″-positions, by metal complexation/de

A PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST

A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c} separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.

Poly(phenylacetylene)s bearing a peptide pendant: Helical conformational changes of the polymer backbone stimulated by the pendant conformational change

Optically active, cis-transoid poly(phenylacetylene) derivatives bearing a poly(γ-benzyl-L-glutamate) [poly-(PBGAm)] or poly(L-glutamic acid) [poly(PGAm)] chain as the pendant were prepared by polymerisation of the corresponding macromonomer with a rhodium catalyst followed by hydrolysis of the pendant ester groups. Their conformational changes in solution, induced by a helix-coil transition of the pendant polypeptides, were investigated using circular dichroism (CD) and absorption spectroscopies. A series of macromonomers with a different peptide chain lengths was synthesised by the polymerisation of the N-carboxyanhydride of γ-benzyl-L-glutamate with a phenylacetylene bearing an alanine residue as the initiator. The obtained macromonomers (PBGAm) were further polymerised with a rhodium catalyst in N,N-dimethylformamide (DMF) to yield novel poly(phenylacetylene)s [poly(PBGAm)] with a poly(γ-benzyl-L-glutamate) pendant. The poly(PBGAm) exhibited an induced circular dichroism (ICD) in the UV/Vis region of the polymer backbone in dimethyl sulfoxide (DMSO), probably due to the prevailing one-handed helix formation. The Cotton effect signs of a DMSO solution of the poly(PBGAm) were inverted and accompanied by a visible colour change in the presence of an increasing amount of chloroform or DMF containing lithium chloride. The results suggest that poly(PBGAm) may undergo a conformational change such as a helix-helix transition with a different helical pitch responding to a change in the α-helix content of the poly(γ-benzyl-L-glutamate) pendant. Moreover, a water-soluble poly(PGAm) also showed a similar, but dramatic change in its helical conformation with a visible colour change stimulated by a helix-coil transition of the pendant poly(L-glutamic acid) chains by changing the pH in water.