19738-90-0

Upstream product

• 1217899-20-1 3-(2,4-dichlorophenyl)-1-phenylprop-2-en-1-ol 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 536-74-3 phenylacetylene 
• 98-86-2 acetophenone 

Downstream Products

• 107916-37-0 2,3-dichloro-3-(2,4-dichloro-phenyl)-1-phenyl-propan-1-one 
• 68257-78-3 3-(2,4-dichloro-phenyl)-4-(3-methyl-4-nitro-isoxazol-5-yl)-1-phenyl-butan-1-one 
• 94360-57-3 cis-1-benzoyl-3,3-dicyano-2-(2,4-dichlorophenyl)cyclopropane 
• 127394-74-5 4-(2,4-Dichloro-phenyl)-2-ethoxy-6-phenyl-nicotinonitrile 
• 94360-04-0 2-[1-(2,4-Dichloro-phenyl)-3-oxo-3-phenyl-propyl]-malononitrile 
• 1094463-27-0 3-(2,4-dichlorophenyl)-1-phenylpropan-1-one 
• 1186044-34-7 diisopropyl 2-(1-(2,4-dichlorophenyl)-3-oxo-3-phenylpropyl)malonate 
• 1247902-03-9 3-cyano-2-(1H-indol-3-yl)-4-(2,4-dichlorophenyl)-6-phenylpyridine 
• 1448042-15-6 1-(2,4-dichloro-phenyl)-3-phenyl-hexa-1,5-dien-3-ol 
• 1384519-18-9 (2S)-2-((R)-1-(2,4-dichlorophenyl)-3-oxo-3-phenylpropyl)cyclohexanone 
• 114456-85-8 5-(2,4-dichlorophenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole 
• 402939-91-7 3-(2,4-dichlorophenyl)-1,5-diphenyl-2-pyrazoline 
• 1322715-68-3 methyl 1-(2,4-dichlorophenyl)-3-oxo-3-phenylpropane-1-sulfonate 
• 1322715-45-6 1-(2,4-dichlorophenyl)-3-oxo-3-phenylpropane-1-sulfonic acid 

Relevant academic research and scientific papers

Bio-derived ZnO nanoflower: A highly efficient catalyst for the synthesis of chalcone derivatives

The green, eco-friendly synthesis of ZnO nanoparticles using the peel of Musa balbisiana and their use as nanocatalysts in the synthesis of chalcones derivatives is reported here. Bio-derived ZnO nanoparticles were characterized by XRD, XPS, FTIR, SEM, BET and TEM techniques. The single step condensation of substituted aryl carbonyls is an attractive feature to obtain substituted chalcones in 88-98% yields in less than 2 min under microwave irradiation in solvent free conditions. A short reaction time with excellent yields of chalcones is the main advantage of our study.

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.

Environmentally benign synthesis of substituted pyrazoles as potent antioxidant agents, characterization and docking studies

Oxidative stress is an important cause of neurogenerative diseases; treatment with a reliable antioxidant with no side effects is a potential tool?to overcome with such diseases. The aim of this study is to explore new and effective antioxidants and their

Rapid umpolung Michael addition of isatin N, N ′-cyclic azomethine imine 1,3-dipoles with chalcones

The umpolung Michael addition of isatin N,N′-cyclic azomethine imine 1,3-dipoles with chalcones is reported. The reaction could be finished within a very short time (0.3-2 min), with 3,3-disubstituted oxindole derivatives obtained in moderate to excellent yields with promising dr values. Unusual Michael adducts were obtained in moderate to high yields (26-98%) with low to high diastereoselectivities (0.8: 1 to 8.5: 1 dr). All the synthesized compounds (3, 3′, 4, 5, 5′, 7, 7′, 9 and 9′) were well characterized by FTIR, NMR, and mass spectral analyses and further confirmed by the single-crystal X-ray diffraction analysis of compounds 3aa and 4n.

Isoxazoles-a biocompatible radical scavenging agents: Citrus juice mediated environmentally benign synthesis and characterization

This study demonstrates the efficient eco-friendly synthesis of a series of isoxazole derivatives 5a-h through (3+2) annulation of chalcones 3a-h and hydroxylamine (4) in citrus juice medium. The synthesized compounds were characterized by spectroscopic a

Application of Polyphosphoric Acid-Mediated Acyl Migration for Regiospecific Synthesis of Diverse 2-Acylpyrroles from Chalcones

A metal-free approach for the synthesis of 2-acylpyrroles is reported in this paper. Synthesis of the target molecule started from chalcones and was carried out in two steps. Initial step involved the conversion of chalcones to corresponding 4-substituted-3-acylpyrroles by reaction with TosMIC. In the subsequent step, target molecules were obtained in modest to good yields by polyphosphoric acid-mediated acyl rearrangement of 3-acylpyrroles to their 2-acyl congeners. The crucial final step was amenable to diverse substitutions on pyrrole ring. Preliminary experiment for the determination of mechanism indicated the involvement of acylium ion.

Design and synthesis of novel natural clinoptilolite-MnFe2O4 nanocomposites and their catalytic application in the facile and efficient synthesis of chalcone derivatives through Claisen-Schmidt reaction

A series of three novel nanocomposites were prepared by modifying the surface of natural clinoptilolite using various amounts of manganese ferrite (MnFe2O4) nanoparticles. These manganese ferrite-modified nanocomposites (MFO–NC) were fully characterized by XRD, FT-IR, EDX, VSM and TEM analyses. One of these novel nanocomposites with 40?wt% of manganese ferrite in clinoptilolite (MFO–NC-3) showed a strong catalytic behavior in the aldol-type Claisen–Schmidt reaction for the synthesis of chalcones. A strong catalytic synergy was observed between nano-MnFe2O4 particles and natural clinoptilolite in the structure of these nanocomposites. The products with a broad range of substituents on the reactants were efficiently obtained under room-temperature conditions within relatively short reaction times with good to excellent yields in the presence of one of the prepared MFO–NC nanocomposites. This nanocomposite also showed a strong stability and substantial reusability in the synthesis of chalcones.

Catalytic Synthesis of Chalcones and Pyrazolines Using Nanorod Vanadatesulfuric Acid: An Efficient and Reusable Catalyst

Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and ecologically benign catalyst, was used for the one-pot synthesis of chalcones and 1,3,5-triaryl-2-pyrazolines (TAPs). Chalcones were prepared via the condensation of substituted acetophenones with aryl-aldehydes under solvent-free conditions. Subsequently, the synthesized chalcones were used for the catalytic synthesis of TAPs via two-component condensation with phenyl hydrazine in refluxing ethanol. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate of high purity. Compared to conventional procedures, the present protocol offers several advantages such as simplicity of the procedure, appropriate reaction times, high to excellent yields, easily work-up, recoverability, and reusability of the catalyst, and simple purification of the products.

Iron(III) phthalocyanine chloride-catalyzed oxidation-aromatization of α,β-unsaturated ketones with hydrazine hydrate: Synthesis of 3,5-disubstituted 1H-pyrazoles

We have developed an iron(III) phthalocyanine chloride-catalyzed oxidation-aromatization of α,β-unsaturated ketones with hydrazine hydrate. Various 3,5-disubstituted 1H-pyrazoles were obtained in good to excellent yields. This method offers several advantages, including room-temperature conditions, short reaction time, high yields, simple work-up procedure, and use of air as an oxidant. The catalyst can be recovered and reused five times without loss of activity.

Synergistic catalysis within TEMPO-functionalized periodic mesoporous organosilica with bridge imidazolium groups in the aerobic oxidation of alcohols

Anchoring 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) within the nanospaces of a periodic mesoporous organosilica with bridged imidazolium groups led to an unprecedented powerful bifunctional catalyst (TEMPO@PMO-IL-Br), which showed enhanced activity in the metal-free aerobic oxidation of alcohols. The catalyst and its precursors were characterized by N2 adsorption-desorption analysis, transmission electron microscopy (TEM), small angle X-ray scattering (SAXS), thermal gravimetric analysis (TGA), diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), solid state electron paramagnetic resonance (EPR) spectroscopy, elemental analysis, transmission electron microscopy (TEM) and high resolution TEM. It was clearly found that the catalytic activity of SBA-15-functionalized TEMPO (TEMPO@SBA-15) not bearing IL, TEMPO@PMO-IL-Cl, PMO-IL-AMP, or individual catalytic functionalities (PMO-IL/TEMPO@SBA-15) was inferior as compared with those obtained from TEMPO@PMO-IL-Br in the metal-free aerobic oxidation of benzyl alcohol, suggesting the critical role of co-supported TEMPO and imidazolium bromide in obtaining high catalytic activity in the described catalyst system. Our observation clearly points to the fact that the combination of imidazolium bromide units in close proximity to TEMPO moieties in the nanospaces of TEMPO@PMO-IL-Br might be indeed one of the key factors explaining the enhanced catalytic activity observed for this catalyst in the oxidation of benzyl alcohol, possibly through a synergistic catalysis relay pathway. A proposed model was suggested for the observed synergistic effect.