19738-92-2

Basic information

• Product Name: 1,3-bis(2,4-dichlorophenyl)prop-2-en-1-one
• Synonyms: 1,3-bis(2,4-dichlorophenyl)prop-2-en-1-one
• CAS NO: 19738-92-2
• Molecular Weight: 346.04
• Mol File: 19738-92-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-bis(2,4-dichlorophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(2,4-dichlorophenyl)prop-2-en-1-one(19738-92-2)
• EPA Substance Registry System: 1,3-bis(2,4-dichlorophenyl)prop-2-en-1-one(19738-92-2)

Safety Data

• Hazardous Substances Data: 19738-92-2(Hazardous Substances Data)

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 

Relevant articles and documents

Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors

A broad range of chalcones and derivatives were easily and rapidly synthesized, following Claisen-Schmidt condensation of (hetero)aryl ketones and (hetero)aryl aldehydes using a ultrasound probe. A comparison was made with classical magnetic stirring experiments, and an optimization study was realized, showing lithium hydroxide to be the best basic catalyst of the studied condensations. By-products of the reactions (β-hydroxy-ketone, diketones, and cyclohexanols) were also isolated. All compounds were evaluated in vitro for their ability to inhibit human farnesyltransferase, a protein implicated in cancer and rare diseases and on the NCI-60 cancer cell lines panel. Molecules showed inhibitory activity on the target protein and cytostatic effect on different cell lines with particular activity against MCF7, breast cancer cells.

Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products

Three natural products, 1,5-diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity. All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities. Compound III with a furyl ring showed strong activities against plant pathogenic fungi. The IC50 of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III2) was 1.20mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug.