197575-01-2

Upstream product

• 598-78-7 L-2-chloropropionic acid 
• 197574-97-3 N-((4aR,6R,7R,8R,8aS)-6-Cyclohexyloxy-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-acetamide 
• 3068-34-6 Acetic acid (2R,3S,4R,5R,6R)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-chloro-tetrahydro-pyran-4-yl ester 
• 108-93-0 cyclohexanol 
• 21588-60-3 cyclohexyl 3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-glucopyranoside 
• 21559-72-8 cyclohexyl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside 

Relevant academic research and scientific papers

Synthesis of hydrophobic derivatives of muramyldipeptides

Methyl esters of the cyclohexyl-, phenethyl-, (2-naphthyl)methyl-, and 2′-(1-naphthyl)ethyl β-glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine have been synthesized. The corresponding glycosides of N-acetylglucosamine were obtained by glycosylating the alcohols with the peracetate of α-glucosaminyl chloride in the presence of HgI2, followed by deacetylation. Subsequent benzylidenation and alkylation with α-L-chloropropionic acid led to glycosylmuramic acids, the condensation of which with the dipeptide and final debenzylidenation gave the desired glycopeptides.